152299-01-9

Upstream product

• 143-33-9 sodium cyanide 
• 152298-92-5 (R)-N,N-dibenzyl-4-<(tert-butyldimethylsilyl)oxy>-2-chloro-1-butylamine 
• 159497-65-1 N,N-dibenzylasparaginic acid dibenzyl ester 
• 152298-97-0 (R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl> methanesulfonate 
• 152299-13-3 (2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol 
• 137428-32-1 (2S)-2-[bis(phenylmethyl)amino]-1,4-butanediol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Relevant academic research and scientific papers

Enantiomerically pure amino alcohols and diamino alcohols from L-aspartic acid. Application to the synthesis of epi- and diepislaframine

Starting from natural aspartic acid (6) a practical method for the synthesis of enantiomerically pure 3-amino alcohols 8 including 3,4-diamino derivatives is described. After perbenzylation of 6 and reduction of both carboxylates, position 4 of the result

PRACTICAL EPC SYNTHESIS OF 1,2- AND 1,3-AMINO ALCOHOLS

An efficient synthesis of enantiomerically pure 1,2- and 1,3-amino alcohols (4,10) through the key intermediates 2 and 8a,b, obtained from L-aspartic acid, is reported.Using 4d as an example it is shown that the products can serve as percursors for unusual amino aldehydes and nonproteinogenic amino acids.