1524-40-9

Basic information

• Product Name: 3-FLUOROBENZENESULFONAMIDE
• Synonyms: 3-FLUOROBENZENESULFONAMIDE;3-FLUOROBENZENESULPHONAMIDE;BUTTPARK 33\11-50;Benzenesulfonamide, 3-fluoro- (9CI);3-FLUOROBENZENESULFO;3-fluorobenzene-1-sulfonaMide;3-Fluorobenzenesulphonamide97%
• CAS NO: 1524-40-9
• Molecular Formula: C₆H₆FNO₂S
• Molecular Weight: 175.18
• Product Categories: SULFONAMIDE;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 1524-40-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 124.5-128.5 °C(lit.)
• Boiling Point: 320.5 °C at 760 mmHg
• Flash Point: 147.6 °C
• Appearance: White to brown/Powder or Crystalline Powder
• Density: 1.428 g/cm³
• Vapor Pressure: 0.000316mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.87±0.60(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-FLUOROBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROBENZENESULFONAMIDE(1524-40-9)
• EPA Substance Registry System: 3-FLUOROBENZENESULFONAMIDE(1524-40-9)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1524-40-9(Hazardous Substances Data)

Usage

Uses

It is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

General Description

3-Fluorobenzenesulfonamide can be synthesized by reacting 3-fluorobenzenesulfonyl chloride (in tetrahydrofuran) with 50% NH4OH.

InChI:InChI=1/C6H6FNO2S/c7-5-2-1-3-6(4-5)11(8,9)10/h1-4H,(H2,8,9,10)

Upstream product

• 2557-77-9 3-fluorothiophenol 
• 935447-39-5 sodium 3-fluorobenzenesulfinate 
• 701-27-9 3-fluorobenzene-1-sulfonyl chloride 
• 128254-27-3 2-Fluoro-1,4-bis-trimethylsilanyl-benzene 
• 7217-41-6 (3-fluorophenyl)trimethylsilane 

Downstream Products

• 189076-95-7 N-(2,2-Dimethyl-propionyl)-3-fluoro-benzenesulfonamide 
• 1159836-09-5 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(3-fluorophenylsulfonyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1112980-02-5 N-(6-(2-(3-fluorophenylsulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide 
• 1094408-95-3 N-(bis-methylsulfanyl-methylidene)-3-fluorobenzenesulfonamide 
• 1191066-56-4 N-(3-fluorobenzenesulfonyl)-4-{[[(4-chlorophenyl)sulfonyl](pyridin-2-yl-methyl)amino]methyl}benzamide 
• 1057257-45-0 C₂₈H₂₁FN₂O₄S 
• 63935-19-3 3-dimethylamino-benzenesulfonic acid amide 

Relevant articles and documents

Fluorescence Assisted Capillary Electrophoresis of Glycans Enabled by the Negatively Charged Auxochromes in 1-Aminopyrenes

A compact and negatively charged acceptor group, N-(cyanamino)sulfonyl, is introduced for dye design and its influence on the absorption and emission spectra of the “push–pull” chromophores is demonstrated with 1,3,6-tris[(cyanamino)sulfonyl]-8-aminopyrene. The new sulfonamides, including O-phosphorylated (3-hydroxyazetidine)-N-sulfonyl, are negatively charged electron acceptors and auxochromes. 1-Aminopyrenes decorated with the new sulfonamides have three or six negative charges (pH ≥8), low m/z ratios, high mobilities in an electric field, and yellow to orange emission. We labeled maltodextrin oligomers by reductive amination, separated the products by electrophoresis, and demonstrated their high brightness in a commercial DNA analyzer and the distribution of the emission signal among the detection channels.

A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

A general and efficient methodology for preparing primary sulfonamides has been developed. In the presence of iodine as the catalyst and TBHP (70% in water) as the oxidant, a wide range of primary sulfonamides were prepared from the corresponding thiols and aqueous ammonia in moderate to good yields.

UNE VOIE ORIGINALE ET SELECTIVE DE FONCTIONNALISATION EN POSITION META DU FLUORO- ET DE L'ETHYLBENZENE

An original and regioselective method for the meta functionalisation of fluoro- and ethylbenze is reported.This process involves a 2,5-disilylation of these subtrates using trimethylchlorosilane in the presence of lithium in THF as the solvent.After aromatisation, monodesilylation in position 2- and electrophilic substitution of the trimethylsilyl group in position 5-, meta acetyl-, senecioyl-, benzoyl-, and iodofluorobenzenes and ethylbenzenes as well as the sodium salts of metafluoro or meta ethylbenzenesulfonic acid and 3-aminosulfonylfluorobenzene were obtained in good yields. pair of diastereomeric triamines 15 and 16.A tricyclic diazasystem 19 was formed from the reaction of cyanide with the carbamoylated chloroenamine 18.Monochloroenamine 10a and dichloroenamine 12a showed a significant mutagenic behaviour in the Ames test.