152401-26-8

Basic information

• Product Name: Ethyl (+/-)-3,4-dehydro-3-methoxymethyl-1-(4-tolylsulfonyl)-pyrrolidine-2-carboxylate
• CAS NO: 152401-26-8
• Molecular Weight: 339.412
• Mol File: 152401-26-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethyl (+/-)-3,4-dehydro-3-methoxymethyl-1-(4-tolylsulfonyl)-pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (+/-)-3,4-dehydro-3-methoxymethyl-1-(4-tolylsulfonyl)-pyrrolidine-2-carboxylate(152401-26-8)
• EPA Substance Registry System: Ethyl (+/-)-3,4-dehydro-3-methoxymethyl-1-(4-tolylsulfonyl)-pyrrolidine-2-carboxylate(152401-26-8)

Safety Data

• Hazardous Substances Data: 152401-26-8(Hazardous Substances Data)

Upstream product

• 5465-67-8 ethyl N-tosylglycinate 
• 43042-58-6 1-methoxybut-3-en-2-one 

Downstream Products

• 27792-82-1 Loroquine 

Relevant articles and documents

Synthesis of 2,3-Dihydro-7-hydroxymethyl-1H-pyrrolizin-1-one, the Alkaloid Loroquine

The title compound 4 is synthesized in 8 steps by cyclization of N-tosylglycinate 5 with vinyl ketone 6.After elimination of water and sulfinic acid the pyrrolecarboxylate 9 is obtained which, on N-alkylation with ethyl acrylate, Dieckmann cyclization, saponification and decarboxylation, yields methylloroquine 12.The reaction with chlorotrimethylsilane/sulfuric acid in acetic anhydride and subsequent saponification gave loroquine (4) in 2.1 percent overall yiels.Key Words: Pheromones / Pyrrolizidine alkaloids / Pyrrolizine / Alkaloids