152404-46-1

Basic information

• Product Name: 4-METHOXYBENZOIC-2,3,5,6-D4 ACID
• Synonyms: 4-Methoxybenzoic--d4 Acid
• CAS NO: 152404-46-1
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 156.17
• Mol File: 152404-46-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHOXYBENZOIC-2,3,5,6-D4 ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZOIC-2,3,5,6-D4 ACID(152404-46-1)
• EPA Substance Registry System: 4-METHOXYBENZOIC-2,3,5,6-D4 ACID(152404-46-1)

Safety Data

• Hazardous Substances Data: 152404-46-1(Hazardous Substances Data)

Upstream product

• 152404-44-9 [2′,3′,5′,6′-d₄]bromophenol 
• 13127-88-3 phenol-d6 
• 100-09-4 4-methoxybenzoic acid 
• 124-38-9 carbon dioxide 
• 152404-45-0 4-bromo-<2,3,5,6-2H4>anisole 

Downstream Products

• 152404-48-3 3,5-dibromo-4-hydroxy-<2,6-2H2>benzoic acid 
• 152404-47-2 [2′,3′,5′,6′-D4]-4′-hydroxybenzoic acid 

Relevant articles and documents

New Pd-phosphorus ylide complexes based on FC60 as heterogeneous nano-catalyst for H/D exchange reaction

In this account, new Pd(0) complexes of phosphorus ylides based on fullerene C60 (FC60) were synthesized and utilized as the first fullerene-based heterogeneous nano-catalysts for H/D exchange reaction. Four new palladacyclopropa-[60]fullerene complexes 1–4, [(η2-C60)Pd(Y1–4)2] (Y1 = PPh3CHC(O)C6H4-p-NO2, Y2 = PPh3CHC(O)C6H4-p-CH3, Y3 = (p-tolyl)3P-CHC(O)C6H4-p-NO2, and Y4 = (p-tolyl)3P-CHC(O)C6H4-p-CH3), were prepared through dissolving the related α-keto stabilized phosphorus ylide in toluene solution in the presence of FC60 and Pd (dba)2 (dba = dibenzylideneacetone). All of the complexes were characterized using Nuclear magnetic resonance (NMR) (1H, 13C, and 31P), Infrared spectroscopy (IR), Ultraviolet-visible spectroscopy (UV-visible), fluorescence, Electrospray Ionisation Mass Spectrometry (ESI-MS), and Energy-dispersive X-ray spectroscopy (EDX) spectroscopies, and scanning electron microscopy (SEM) and TEM techniques. The data proved that FC60 and two ylides were coordinated to Pd(0) center through two hexagons and two ylidic carbon atoms, respectively. An evaluation was also performed to compare the catalytic activity of synthesized Pd complex 1 and a conventional heterogeneous catalyst, 10% Pd on carbon, in H/D exchange reaction. The results indicate that the process of H/D exchange reaction in aromatic rings of benzoic acid derivatives progressed more efficiently by Pd complex 1.

A simple procedure for the deuteriation of phenols

A simple procedure for the deuteriation of a large range of phenols has been developed using Amberlyst 15, a polymer supported acid catalyst. A number of phenols present in olive oil have been successfully deuteriated. The aromatic protons of hydroxytyrosol are 100% exchanged under the conditions used. This method is applicable for the tritiation of phenols.

Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus

The biosynthesis of the antibiotic reductiomycin (1) in Streptomyces xanthochromogenus was investigated by feeding experiments with radioactive and stable isotope-labeled precursors. NMR and mass spectroscopic analyses of the labeled 1 samples revealed th