152441-67-3Relevant academic research and scientific papers
A peptide-embedded trifluoromethyl ketone catalyst for enantioselective epoxidation
Romney, David K.,Miller, Scott J.
, p. 1138 - 1141 (2012)
The development of peptide-based oxidation catalysts that use a transiently generated dioxirane as the chemically active species is reported. The active catalyst is a chiral trifluoromethyl ketone (Tfk) with a pendant carboxylic acid that can be readily incorporated into a peptide. These peptides were capable of epoxidizing alkenes in high yield (up to 89%) and enantiomeric ratios (er) ranging from 69.0:31.0 to 91.0:9.0, depending on the alkene substitution pattern.
The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives
Trybulski,Zhang,Kramss,Mangano
, p. 3533 - 3541 (2007/10/02)
Previous pharmacological studies of methylated oxotremorine derivatives bearing substituents at the 3-, 4-, and 5-positions of the pyrrolidinone ring have been conducted using racemic mixtures, and not with optically active compounds. The synthesis and radioligand binding data of optically active, methylated oxotremorine derivatives at the 3- and 4-positions are described. There are significant pharmacological differences between the 3- and 4- position derivatives. The 4-position enantiomers have weak, approximately equal affinity and antagonist-like profiles, whereas the 3-position enantiomers have significantly different affinities and partial agonist-like profiles.
Influence of the ester group during the enantioselective methylation of α-aldehyde esters via their chiral oxazolidine derivatives
Agami, Claude,Couty, Franc ois
, p. 5659 - 5660 (2007/10/02)
Depending on the nature of the ester group, fair asymmetric induction (ee's up to 82%) can be attained in the title reaction.
