152452-80-7Relevant academic research and scientific papers
Synthesis and biological activities of [E]-5-(2-acylvinyl)uracils
Kundu,Dasgupta,Chaudhuri,Mahanty,Spears,Shahinian
, p. 473 - 479 (1993)
The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.
