European Journal of Medicinal Chemistry p. 473 - 479 (1993)
Update date:2022-08-04
Topics:
Kundu
Dasgupta
Chaudhuri
Mahanty
Spears
Shahinian
The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.
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Doi:10.1080/00397919308013802
(1993)Doi:10.1080/10426507.2010.497519
(2011)Doi:10.1021/jf4046683
(2014)Doi:10.1021/jo402626u
(2014)Doi:10.1016/0008-6215(93)84121-L
(1993)Doi:10.1016/S0040-4039(00)91835-5
(1993)
