Synthesis and biological activities of [E]-5-(2-acylvinyl)uracils

DOI: 10.1016/0223-5234(93)90015-7

Source and publish data:

European Journal of Medicinal Chemistry p. 473 - 479 (1993)

Update date:2022-08-04

Topics:

Authors:

Kundu Kundu

Dasgupta

Chaudhuri

Mahanty Mahanty

Spears Spears

Shahinian

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Article abstract of DOI:10.1016/0223-5234(93)90015-7

The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.

Full text of DOI:10.1016/0223-5234(93)90015-7

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