152453-71-9

Upstream product

• 67320-20-1 1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-bis-ethylsulfanyl-propan-1-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 326921-58-8 (2R,3S,5Z)-3-p-methoxybenzyloxyoct-5-ene-1,2-diol 
• 326921-49-7 (1'S,3'Z,4R)-4-(1'-p-methoxybenzyloxyhex-3'-enyl)-2,2-dimethyl-1,3-dioxolane 
• 326921-59-9 (2R,3S,5Z)-2-hydroxy-3-p-methoxybenzyloxyoct-5-enyl pivalate 
• 326921-51-1 (2R,3S,5Z)-2-t-butyldimethylsilyloxy-3-p-methoxybenzyloxy-5-octenal 
• 326921-63-5 (2R,3S,5Z)-2-t-butyldimethylsilyloxy-3-p-methoxybenzyloxyoct-5-en-1-ol 
• 326921-50-0 (2R,3S,5Z)-2-t-butyldimethylsilyloxy-3-p-methoxybenzyloxyoct-5-enyl pivalate 
• 345994-29-8 (9S,10E,12R,13S,15Z)-12-t-butyldimethylsilyloxy-13-p-methoxybenzyloxyoctadeca-10,15-dien-9-olide 
• 345994-38-9 (9S,10E,12R,13S,15Z)-13-t-butyldiphenylsilyloxy-12-hydroxyoctadeca-10,15-dien-9-olide 
• 326921-52-2 methyl (10E,12R,13S,15Z)-12-t-butyldimethylsilyloxy-13-p-methoxybenzyloxy-9-oxooctadeca-10,15-dienoate 
• 326921-53-3 methyl (9R,10E,12R,13S,15Z)-12-t-butyldimethylsilyloxy-9-hydroxy-13-p-methoxybenzyloxyoctadeca-10,15-dienoate 
• 345994-22-1 methyl (9S,10E,12R,13S,15Z)-12-t-butyldimethylsilyloxy-9-hydroxy-13-p-methoxybenzyloxyoctadeca-10,15-dienoate 
• 345994-12-9 (9R,10E,12R,13S,15Z)-12-t-butyldimethylsilyloxy-9-hydroxy-13-p-methoxybenzyloxyoctadeca-10,15-dienoic acid 
• 326921-60-2 (9S,10E,12R,13S,15Z)-12-t-butyldimethylsilyloxy-9-hydroxy-13-p-methoxybenzyloxyoctadeca-10,15-dienoic acid 
• 345994-36-7 (9S,10E,12R,13S,15Z)-12-t-butyldimethylsilyloxy-13-t-butyldiphenylsilyloxyoctadeca-10,15-dien-9-olide 

Relevant academic research and scientific papers

First total synthesis of mueggelone

All the four possible stereoisomers of mueggelone, an inhibitor of fish development, were efficiently synthesized in a stereoselective manner starting from D-arabinose, and the absolute configuration was determined to be 9R,12S, 13S. (C) 2000 Elsevier Science Ltd.

LAULIMALIDE ANALOGS AND USES THEREOF

The present invention provides compounds having formula 1: (I) and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation.

First total synthesis and determination of the absolute configuration of mueggelone

All the four possible stereoisomers of mueggelone, an inhibitor of fish development, were efficiently synthesized in a stereoselective manner starting from D-arabinose, and the absolute configuration was determined to be 9R, 12S, 13S.

Synthesis of two new maytansinoid model compounds from carbohydrate precursors

Maytansine (1) is a macrocyclic natural product with significant anti-cancer activity. A derivative (4) of D-glucal is converted to a model compound (10) for the lower periphery of the maytansinoid ring via alkylation at C-6 using an allylic sulfide anion

Total synthesis of the macrolide antitumor antibiotic lankacidin C

The first total synthesis of natural (-)-lankacidin C (1) has been achieved by a convergent, enantioselective sequence starting from D-arabinose and L-aspartic acid, proceeding through the tricyclic carbamate 15 as an advanced relay intermediate. Specific