15249-82-8

Usage

Uses

Used in Organic Synthesis:
(3,4-DIPHENYL-3H-THIAZOL-2-YLIDENE)-PHENYL-AMINE is used as a key building block for the synthesis of various organic compounds. Its unique structure allows for the creation of a diverse range of molecules with potential applications in different industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3,4-DIPHENYL-3H-THIAZOL-2-YLIDENE)-PHENYL-AMINE is employed as a precursor in the development of pharmaceutical drugs. Its structural properties make it a valuable component in the design and synthesis of new therapeutic agents.
Used in Laboratory Research:
As a reagent in laboratory research, (3,4-DIPHENYL-3H-THIAZOL-2-YLIDENE)-PHENYL-AMINE aids scientists in conducting experiments and advancing their understanding of chemical reactions and processes.
Used in Agrochemical Development:
(3,4-DIPHENYL-3H-THIAZOL-2-YLIDENE)-PHENYL-AMINE is utilized in the development of agrochemicals, contributing to the creation of products that can enhance crop protection and agricultural productivity.
Used in Materials Science:
In materials science, (3,4-DIPHENYL-3H-THIAZOL-2-YLIDENE)-PHENYL-AMINE is used to develop new materials with specific properties, such as improved stability, reactivity, or other characteristics that can be beneficial in various applications.
It is crucial to handle and store (3,4-DIPHENYL-3H-THIAZOL-2-YLIDENE)-PHENYL-AMINE with care due to its potential health and environmental risks, ensuring that proper safety measures are in place throughout its use in research and development.

Upstream product

• 3898-08-6 1,1-diphenylthiourea 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 102-08-9 N,N-diphenylthiourea 
• 14739-28-7 5-phenyl-2-phenylimino-1,3-oxathiole 
• 103-71-9 phenyl isocyanate 
• 103-72-0 phenyl isothiocyanate 
• 4651-78-9 2-bromo-1-phenylethylidenemalononitrile 
• 705-62-4 N,N-dimethyl-N'-phenylthiourea 
• 3282-32-4 2-diazo-acetophenone 

Downstream Products

• 103-72-0 phenyl isothiocyanate 

Relevant academic research and scientific papers

Aqueous-phase synthesis of 2-aminothiazole and 2-iminothiazolidine derivatives catalyzed by diammonium hydrogen phosphate and DABCO

2-Aminothiazole and 2-iminothiazolidine derivatives were synthesized from the reaction of phenacyl bromide, thiourea, and its derivatives in aqueous media catalyzed by diammonium hydrogen phosphate (10%) and DABCO (10%) at room temperature in an efficient and simple procedure. Copyright Taylor & Francis Group, LLC.

Condensation of (2-Bromo-1-phenylethylidene)malononitrile with Substituted Thioureas: An Unusual Ring Size Effect

Condensations of the title electrophile with ambient S,N-nucleophiles, e.g., thiourea, N,N'-diphenylthiourea, and thiosemicarbazide, proceed via initial S-alkylation followed by closure of the thiazole ring.In contrast to this, cyclic thioureas with the five-, six- and seven-membered rings afford distinct condensation products depending on the size of the ring. 2-Imidazolinethione gave 7-cyano-2,3-dihydro-5-mercapto-6-phenyl-1H-pyrrolo-imidazole in low yield. 3,4,5,6-Tetrahydro-2(1H)-pyrimidinethione afforded malonitrile in high yield, while 1,3,4,5,6,7-hexahydro-2H-1,3-diazepine-2-thione gave 7-amino-8-cyano-9-phenyl-2,3,4,5-tetrahydropyridodiazepine in moderate yield.A common feature of these cyclizations is the primary S-nucleophilic attack, which was confirmed by isolation and characterization of the corresponding intermediates.The effects of ring size are discussed.

Reactions of N,N-Dialkyl-N'-arylthioureas with α-Haloketones and of 2-Substituted Imino-1,3-oxathioles with Heterocumulenes

N,N-Dialkyl-N'-arylthioureas react with phenacyl halides to give 2-arylimino-5-phenyl-1,3-oxathioles (I), 3-aryl-2-arylimino-4-phenyl-4-thiazolines (III), aryl isothiocyanates and N,N'-diarylthioureas.I reacts with heterocumulenes like phenyl isocyanate and phenyl isothiocyanate to give 3,4-diaryl-2-arylimino-4-thiazolines, N,N'-diarylthioureas, arylacetylenes and COS or CO2.Mechanisms of formation of the various products have been proposed, based on TLC monitoring at regular time intervals.These are independently supported by chemical reactions.