152500-20-4Relevant academic research and scientific papers
Enantioselective synthesis of 5-substituted and 3,5-disubstituted-2-formylpyrrolidine derivatives, the key D-ring fragments of (-)-quinocarcin and (-)-10-decarboxyquinocarcin
Katoh,Nagata,Kobayashi,Arai,Minami,Terashima
, p. 5743 - 5746 (1993)
The title synthesis was achieved starting from (S)-glutamic acid and (S)-pyroglutamic acid by featuring formation of an N-protected aminal, substitution of the methoxy group with cyanide anion, and reduction of the cyanide to an aldehyde as common key steps.
Synthetic studies on quinocarcin and its related compounds. 3. Synthesis of 5-substituted- and 3,5-disubstituted-2-formyl-pyrrolidine derivatives, the key D-ring fragments of enantiomeric pairs of quinocarcin and 1
Katoh, Tadashi,Nagata, Yuriko,Kobayashi, Yuko,Arai, Katsuko,Minami, Junko,Terashima, Shiro
, p. 6221 - 6238 (2007/10/02)
The title synthesis was accomplished by employing each enantiomer of glutamic acid and pyroglutamic acid as chiral starting materials.
