152500-52-2

Upstream product

• 154978-02-6 (1R,3S)-3-((2R,5S)-5-Benzyloxymethyl-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-8-methoxy-1-((1R,2R)-1,2,3-trihydroxy-propyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 152500-49-7 (1R,3R)-2,2,2-trichloroethyl 3-<(2R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonylpyrrolidin-2-yl>-1-<(4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl>-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate 
• 152500-44-2 (4R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-<2-<(4S,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methoxyphenyl>acetylpyrrolidine 
• 152500-46-4 3-<(2R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonylpyrrolidin-2-yl>-1-<(4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl>-8-methoxyisoquinoline 
• 152500-48-6 (1R,3R)-3-<(2R,5S)-4-benzyloxymethyl-1-tert-butoxycarbonylpyrrolidin-2-yl>-1-<(4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl>-8-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 152500-41-9 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole 
• 152500-43-1 2-<(4S,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole 
• 152500-42-0 2-<(4S,5R)-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole 
• 38197-43-2 2-bromo-3-methylanisole 
• 154978-03-7 (1R,3S)-3-((2R,5S)-5-Benzyloxymethyl-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-1-formyl-8-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 154978-04-8 (1R,3R)-2,2,2-trichloroethyl 1-acetoxymethyl-3-<(2R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonylpyrrolidin-2-yl>-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate 

Relevant academic research and scientific papers

Synthetic Studies on Quinocarcin and Its Related Compounds. 4. Total Synthesis of Enantiomeric Pairs of Quinocarcin and 10-Decarboxyquinocarcin

The title synthesis was accomplished by featuring (i) aldol coupling of the 3-methylanisole 11 with 5-substituted- or 3,5-disubstituted- 2-formylpyrrolidine 4 or 5, (ii) highly diastereoselective reduction of 1,3-disubstituted isoquinolines 14 and 33 to c

Total Synthesis of (-)-Quinocarcin and (-)-10-Decarboxyquinocarcin

The title total synthesis was accomplished by employing diastereoselective reduction of 1,3-disubstituted isoquinolines as a key step.The cytotoxicity of 10-decarboxyquinocarcin and its 7-cyano congeners were found to be 10-1000 times more potent than tho