152510-47-9Relevant academic research and scientific papers
Large Scale Synthesis of an Ampakine-type Active Pharmaceutical Ingredient Based on a Telescoped Regioselective Double Amidation Reaction
Hardouin, Christophe,Pin, Frédéric,Giffard, Jean-Fran?ois,Hervouet, Yvon,Hublet, Julie,Janvier, Solenn,Penloup, Christine,Picard, Julien,Pinault, Nathalie,Schiavi, Bruno,Zhang, Peng,Zhao, Weiwei,Zhu, Xueyan
, p. 1932 - 1947 (2019/10/11)
This work describes the process development and manufacture of an ampakine-type active pharmaceutical ingredient in clinical trials. A regioselective CDI-mediated amidation process was optimized for the subsequent couplings of two distinctive amines with
PROLYL HYDROXYLASE INHIBITORS
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Page/Page column 23-24, (2010/07/10)
The invention described herein relates to certain 2,4-dioxo-l,2,3,4-tetrahydro-7- quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
