152532-10-0

Basic information

• Product Name: 3-oxo-N-(2,4,5-trimethoxyphenyl)butanamide
• Synonyms: 3-oxo-N-(2,4,5-trimethoxyphenyl)butanamide;Butanamide, 3-oxo-N-(2,4,5-trimethoxyphenyl)-
• CAS NO: 152532-10-0
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.28
• Mol File: 152532-10-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 90-92 °C
• Boiling Point: 434.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.189±0.06 g/cm3(Predicted)
• PKA: 10.87±0.46(Predicted)
• CAS DataBase Reference: 3-oxo-N-(2,4,5-trimethoxyphenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxo-N-(2,4,5-trimethoxyphenyl)butanamide(152532-10-0)
• EPA Substance Registry System: 3-oxo-N-(2,4,5-trimethoxyphenyl)butanamide(152532-10-0)

Safety Data

• Hazardous Substances Data: 152532-10-0(Hazardous Substances Data)

Upstream product

• 691-45-2 acetylketene 
• 26510-91-8 2,4,5-trimethoxyaniline 
• 141-97-9 ethyl acetoacetate 

Relevant articles and documents

Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities

An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors. In addition, X-ray crystallography studies of QR2 in complex with compound 1 and one of its more potent analogues has provided insight into the mechanism of action of this new series of QR2 inhibitors. The initial biological investigations suggest that compound 1 and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents.