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26510-91-8

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26510-91-8 Usage

Uses

2,4,5-Trimethoxyaniline is used in preparation of Quinoline-5,8-dione derivatives as TGase 2 inhibitor.

Check Digit Verification of cas no

The CAS Registry Mumber 26510-91-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,5,1 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 26510-91:
(7*2)+(6*6)+(5*5)+(4*1)+(3*0)+(2*9)+(1*1)=98
98 % 10 = 8
So 26510-91-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H13NO3/c1-11-7-5-9(13-3)8(12-2)4-6(7)10/h4-5H,10H2,1-3H3

26510-91-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4,5-Trimethoxyaniline

1.2 Other means of identification

Product number -
Other names 5-Amino-oxyhydrochinon-trimethylaether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:26510-91-8 SDS

26510-91-8Relevant articles and documents

Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

González, Myriam,Ovejero-Sánchez, María,Vicente-Blázquez, Alba,Medarde, Manuel,González-Sarmiento, Rogelio,Peláez, Rafael

, p. 1029 - 1047 (2021/06/16)

Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa and HT-29 human tumour cell lines, and were particularly effective against MCF7. The most potent series has 2,5-dimethoxyanilines, especially the 4-brominated compounds 23–25. The active compounds inhibit microtubular protein polymerisation at micromolar concentrations, thus pointing at tubulin as the target. Co-treatment with the MDR inhibitor verapamil suggests that they are not MDR substrates. Compound 25 showed nanomolar antiproliferative potency. It severely disrupts the microtubule network in cells and arrests cells at the G2/M cell-cycle phase, thus confirming tubulin targeting. 25 triggered apoptotic cell death, and induced autophagy. Docking studies suggest binding in a distinct way to the colchicine site. These compounds are promising new antitumor agents acting on tubulin.

Quinoline-5,8-dione derivatives for TGase 2 inhibitor, and the pharmaceutical composition comprising the same

-

Paragraph 0186; 0190-0192, (2019/10/29)

The present invention relates to a quinolin-5,8-dione derivative compound represented by chemical formula I, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The compound represented by chemical formula I of the present invention has a TGase 2 inhibitory effect, and the pharmaceutical composition comprising the same can be usefully used for preventing or treating disorders or diseases mediated by TGase 2 or response to TGase 2 inhibition.COPYRIGHT KIPO 2020

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, Kunal,Kumar, Sunil,Huang, Hsiang-Ling,Kuo, Fei-Chiao,Lee, Cheng-Hsin,Kuo, Ching-Chuan,Yeh, Teng-Kuang,Li, Yu-Hsuan,Chang, Jang-Yang,Liou, Jing-Ping,Lee, Hsueh-Yun

, p. 716 - 723 (2016/01/12)

This study reports the synthesis of a series of 2-aroylquinoline-5,8-diones (11-23) on the basis of scaffold hopping. The presence of a methoxy group at C6 assists the highly regioselective incorporation with various amines, and simplifies the structural

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