15255-66-0Relevant academic research and scientific papers
Cu catalyzed cross-dehydrogenative coupling reaction for the synthesis of 3-hydroxy-2-pyrrolidinones
Sarkar, Rajib,Mukhopadhyay, Chhanda
supporting information, p. 3069 - 3076 (2018/07/06)
A new convenient strategy for the synthesis of 3-hydroxy-2-pyrrolidinone derivatives featuring regioselective C–C coupling has been developed. This is a Cu (II) catalyzed cross dehydrogenative coupling (CDC) involving enamino-ketones of benzyl amines and di-alkyl acetylenedicarboxylate, followed by cyclization by primary amines. TBHP (tert-butyl hydroperoxide) has been used as the oxidant to promote the coupling protocol. This synthetic route principally demonstrates the scope of CDC reaction and also applicable to gram-scale synthesis.
Intramolecular [2 + 2] photocvcloaddition of N-alkenovl-β-enaminones
Amougay, Aicha,Pete, Jean-Pierre,Piva, Olivier
, p. 625 - 635 (2007/10/03)
The photolysis of cyclic N-alkenoyl β-enaminones is described. In general, a very regio- and stereoselective intramolecular [2 + 2] photocydoaddition was observed. The limitations of the reaction process are discussed. The main competitive reaction, which
