15256-10-7

Basic information

• Product Name: 4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE
• Synonyms: 4-[(AMINOOXY)METHYL]-1,2-DICHLOROBENZENE HYDROCHLORIDE;4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE;O-(3,4-Dichlorobenzyl)hydroxylamine hydrochloride;(3,4-dichlorophenyl)methoxyazanium,chloride
• CAS NO: 15256-10-7
• Molecular Formula: C₇H₇Cl₂NO*ClH
• Molecular Weight: 228.5
• Mol File: 15256-10-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 195°
• Boiling Point: 195°C
• Flash Point: 158.8°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 6.77E-05mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)
• CAS DataBase Reference: 4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE(15256-10-7)
• EPA Substance Registry System: 4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE(15256-10-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 15256-10-7(Hazardous Substances Data)

Usage

Description

4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE, also known as 4-[(Aminooxy)methyl]-1,2-dichlorobenzene hydrochloride, is a chemical compound with the molecular formula C7H7Cl2NO. It is characterized by its ability to act as an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1), making it a potential candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE is used as an inhibitor for indoleamine 2,3-dioxygenase-1 (IDO1) for its potential therapeutic applications in the treatment of cancer, chronic viral infections, and other diseases characterized by pathologies involving IDO1 overexpression.
Used in Cancer Treatment:
4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE is used as an anticancer agent, targeting IDO1, which plays a role in tumor growth and immune evasion. By inhibiting IDO1, this compound may help in the development of novel cancer therapies and improve the effectiveness of existing treatments.
Used in Chronic Viral Infections Treatment:
4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE is used as an antiviral agent, targeting IDO1, which is involved in the pathogenesis of chronic viral infections. Inhibiting IDO1 may help in the development of new treatments for such infections by modulating the immune response and reducing viral persistence.
Used in Other Disease Treatments:
4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE is used as a therapeutic agent for diseases characterized by pathologies involving IDO1 overexpression. By targeting IDO1, this compound may help in the development of novel treatments for a range of conditions beyond cancer and chronic viral infections.

InChI:InChI=1/C7H7Cl2NO.ClH/c8-6-2-1-5(4-11-10)3-7(6)9;/h1-3H,4,10H2;1H

Upstream product

• 1805-32-9 3,4-dichlorobenzyl alcohol 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 38936-82-2 2-(3,4-dichlorobenzyloxy)isoindole-1,3-dione 
• 84772-12-3 O-[(3,4-dichlorophenyl)methyl]hydroxylamine 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 

Downstream Products

• 133327-09-0 4-(3,4-Dichlor-benzyloxy)-allophansaeure-(3,4-dichlor-benzylester) 
• 1174758-21-4 tert-butyl N-(3,4-dichlorobenzyloxy)carbamate 
• 880471-91-0 C₁₅H₁₀Cl₃F₃N₂O₃S 
• 880473-83-6 C₂₁H₁₄Cl₃F₃N₂O₃S 

Relevant articles and documents

Synthesis and antibacterial evaluation of (E)-1-(1H-indol-3-yl) ethanone O-benzyl oxime derivatives against MRSA and VRSA strains

Infections caused due to multidrug resistant organisms have emerged as a constant menace to human health. Even though numerous antibiotics are currently available for treating infectious diseases, a great number of bacterial strains have acquired resistance to many of them. Among these, infections caused due to Staphylococcus aureus are predominant in adult and paediatric population. Indole is a prominent chemical scaffold found in many pharmacologically active natural products and synthetic drugs. A number of oxime ether containing compounds have attracted attention of researchers owing to their interesting biological properties. Current work details the synthesis of indole containing oxime ether derivatives and their evaluation for antimicrobial activity against a panel of bacterial and mycobacterial strains. Synthesized compounds demonstrated good to moderate activity against drug-resistant S. aureus including resistant to vancomycin. Among all, compound 5h was found to possess potent activity against susceptible as well as MRSA and VRSA strains of S. aureus with MIC of 1 μg/mL and 2–4 μg/mL respectively. In addition, compound 5h was found to be non-toxic to Vero cells and exhibited good selectivity index of >40. Further, 5h, E-9a and E-9b possessed good biofilm inhibition against S. aureus. With these assuring biological properties, synthesized compounds could be potential prospective antimicrobial agents.

Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives

Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.