152560-66-2Relevant academic research and scientific papers
Efficient synthesis of 2- and 3-substituted-2,3-dihydro [1,4]dioxino[2,3-b]pyridine derivatives
Lazar,Soukri,Leger,Jarry,Akssira,Chirita,Grig-Alexa,Finaru,Guillaumet
, p. 6461 - 6473 (2007/10/03)
A versatile new approach for the synthesis in three steps of 2-substituted-2,3-dihydro[1,4]dioxino[2,3-b]pyridines B via a Smiles rearrangement using easily available reagents is described. A study illustrating the influence of experimental conditions on the progress of the reaction is reported.
A NEW SYNTHETIC ROUTE TO THE PREVIOUSLY UNATTAINABLE 3-SUBSTITUTED 2,3-DIHYDRO-1,4-DIOXINOPYRIDINES
Benarab, Abdelhakim,Poirot, Pascal,Guillaumet, Gerald
, p. 1589 - 1599 (2007/10/02)
A variety of 3-substituted-2,3-dihydro-1,4-dioxino-pyridines (3) have been synthesized from the readily available 2-chloro-3-oxiranyl-methoxypyridine (1).Treatment of this epoxide by various nucleophile reagents provided alcohols (2a-i) which, by displacement of the chlorine, gave the desired products (3a-i) in satisfactory yields.
