6636-78-8

Basic information

• Product Name: 2-Chloro-3-hydroxypyridine
• Synonyms: 2-Chloro-3-hydroxypyridine≥ 99% (HPLC);2-CHLORO-PYRIDINE-3-OL;2-CHLOROPYRIDIN-3-OL;2-CHLORO-3-HYDROXYPYRIDINE;2-CHLORO-3-PYRIDINOL;2-chloro-3-pyridino;3-Pyridinol, 2-chloro-;2-chloro-3-hdyroxypyridine
• CAS NO: 6636-78-8
• Molecular Formula: C5H4ClNO
• Molecular Weight: 129.54
• EINECS: 229-635-3
• Product Categories: PYRIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines derivatives;Halides;Pyridines;Chloropyridines;Halopyridines;Imidazoles
• Mol File: 6636-78-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 170-172 °C(lit.)
• Boiling Point: 316.2 °C at 760 mmHg
• Flash Point: 145 °C
• Appearance: Light beige/Powder
• Density: 1.2309 (rough estimate)
• Vapor Pressure: 0.000225mmHg at 25°C
• Refractive Index: 1.4510 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.32±0.10(Predicted)
• BRN: 2216
• CAS DataBase Reference: 2-Chloro-3-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-hydroxypyridine(6636-78-8)
• EPA Substance Registry System: 2-Chloro-3-hydroxypyridine(6636-78-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-24/25-36
• WGK Germany: 3
• RTECS: UU7707000
• HazardClass: IRRITANT
• Hazardous Substances Data: 6636-78-8(Hazardous Substances Data)

Usage

Chemical Properties

light beige powder

Uses

2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2( 1 H)-selone. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions.

InChI:InChI=1/C5H4ClNO/c6-5-4(8)2-1-3-7-5/h1-3,8H

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 15128-82-2 3-hydroxy-2-nitropyridine 
• 109-09-1 2-chloropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 89694-54-2 2-bromo-3-ethoxypyridine 
• 38729-14-5 2-nitro-1-oxy-pyridin-3-ol 
• 6298-19-7 2-chloro-3-aminopyridine 
• 74885-85-1 3-(Formyloxy)pyridin 
• 27039-14-1 benzoic acid 3-pyridyl ester 
• 163083-47-4 2-chloropyridin-3-yl trifluoromethanesulfonate 
• 462-08-8 pyridin-3-ylamine 
• 6602-28-4 3-hydroxypyridine N-oxide 
• 452972-11-1 2-[(2-chloro)pyridin-3-yl]-4,4',5,5'-tetramethyl-1,3-dioxaborolane 
• 381248-04-0 (2-chloropyridin-3-yl)boronic acid 

Downstream Products

• 141843-91-6 Phosphoric acid dibenzyl ester 2-chloro-pyridin-3-yl ester 
• 153332-60-6 1-acetoxy-2-(2-chloro-3-pyridinyloxy)-3-benzyloxypropane 
• 108082-72-0 2-chloro-3-benzyloxypyridine 
• 152560-63-9 2-chloro-3-(oxiranylmethoxy)-pyridine 
• 3308-02-9 3-hydroxy-2-phenylpyridine 
• 52605-96-6 2-chloro-3-methoxypyridine 
• 73406-93-6 2-chloro-3-phenoxypyridine 
• 478148-61-7 furo[2,3-c]pyridine-5-carbaldehyde 
• 478148-60-6 furo[2,3-c]pyridin-5-yl methanol 
• 478148-62-8 furo[2,3-c]pyridine-5-carboxylic acid 
• 478149-53-0 PHA-543613 
• 208519-37-3 2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine 
• 208519-38-4 2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol 
• 318462-30-5 [(4-Fluorobenzenesulfonylamino)methyl]-phosphonic Acid mono-(2-Chloropyridin-3-yl)ester Sodium Salt 

Relevant articles and documents

Preparation method of 2,3-dichloropyridine

The invention provides a preparation method of 2,3-dichloropyridine. The 2,3-dichloropyridine is prepared by a one-pot method, pyridine alkyl ester serves as a raw material, and synthesis is conductedby a mode of performing chlorination, performing hydrolysis and performing chlorination again; the chlorination is substitution reaction, substitution on a benzene ring is relatively easy, the alkylester group can protect the site of the first-time chlorination reaction to be at 2 position, the hydrolysis reaction is mild in condition and rapid in reaction compared with the prior art, the second-time chlorination is to substitute the hydroxyl, the reaction is easy and the reaction condition is relatively mild. The preparation method provided by the invention is simple in operation, few threewastes are generated in the production process, requirements on equipment are low and the yield is high.

Cesium carbonate mediated aryl triflate esters' deprotection

A variety of diversely substituted aryl triflate esters were efficiently deprotected to the parent phenols by exposure to cesium carbonate in toluene. This procedure proved highly compatible with existing functional groups.

Method for producing an optically active 1-substituted 2-propanol

A method for producing an optically active 1-substituted 2-propanol of the following formula 1, which comprises reacting a hydroxy aromatic compound of the following formula 2 with an optically active propylene oxide in the presence of a catalyst:AOH??Formula 2CH3C*H(OH)CH2OA??Formula 1wherein A is a univalent aromatic group, and C* is an asymmetric carbon atom.