152574-71-5Relevant academic research and scientific papers
Ruthenium(ii)-catalyzed intermolecular annulation of alkenyl sulfonamides with alkynes: Access to bicyclic sultams
Qian, Lei-Lei,Min, Xiang-Ting,Hu, Yan-Cheng,Shen, Bing-Xue,Yang, Sa-Na,Wan, Boshun,Chen, Qing-An
supporting information, p. 2614 - 2617 (2020/03/10)
A ruthenium-catalyzed allylic C(sp3)-H activation strategy has been employed to develop an intermolecular coupling of alkenyl sulfonamides with alkynes. This protocol features the diastereoselective construction of [3.3.0] and [4.3.0] bicyclic sultams in one step.
The Synthesis of Benzofulvenes through Palladium-Catalyzed Sequential Three-Component Reactions
Zhou, Bo,Wu, Zhuo,Qi, Weixin,Sun, Xueliang,Zhang, Yanghui
supporting information, p. 4480 - 4484 (2018/10/31)
An approach for the synthesis of benzofulvenes has been developed through palladium-catalyzed sequential three-component reactions. The reactions likely involve C,C-palladacycles as the key intermediates. The palladacycles are generated through cascade reactions of aryl halides and alkynes, and then reacted with CH2Br2 to form benzofulvenes as the final products. (Figure presented.).
Pyrrole synthesis via allylic sp3 C-H activation of enamines followed by intermolecular coupling with unactivated alkynes
Rakshit, Souvik,Patureau, Frederic W.,Glorius, Frank
supporting information; experimental part, p. 9585 - 9587 (2010/09/10)
A conceptually novel pyrrole synthesis is reported, efficiently merging enamines and (unactivated) alkynes under oxidative conditions. In an intermolecular Rh catalyzed process, the challenging allylic sp3 C-H activation of the enamine substrates is followed by the cyclization with the alkyne (R3 = CO2R). Alternatively, in some cases (R 3 = CN), the enamine can be utilized for a vinylic sp2 C-H activation. A total of 17 examples with yields above 60% is presented, together with the results of an initial mechanistic investigation.
Ethynyl-cyclohexanol: an efficient acetylene surrogate in Sonogashira coupling
Csékei, Márton,Novák, Zoltán,Kotschy, András
, p. 975 - 982 (2008/09/17)
The Sonogashira coupling of aryl halides in the presence of 1-ethynyl-cyclohexanol as an acetylene source provides an efficient method for the synthesis of diarylacetylenes without the isolation of the appropriate arylacetylenes.
One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction.
Mio, Matthew J,Kopel, Lucas C,Braun, Julia B,Gadzikwa, Tendai L,Hull, Kami L,Brisbois, Ronald G,Markworth, Christopher J,Grieco, Paul A
, p. 3199 - 3202 (2007/10/03)
A modification of the Sonogoshira coupling reaction employing an amidine base and a substoichiometric amount of water generates symmetrical and unsymmetrical bisarylethynylenes in one pot through in situ deprotection of trimethylsilylethynylene-added intermediates.
Oxidation of Aromatic Compounds. IV. Oxidation of Symmetrical Diarylacetylenes in the CF3COOH-CH2Cl2-PbO2 System. A New One-Pot Synthesis of 1,2,3,4-Tetraaryl-2-butene-1,4-diones
Rudenko, A. P.,Vasil'ev, A. V.
, p. 1360 - 1379 (2007/10/03)
Oxidation of symmetrical diarylacetylenes in the CF3COOH-CH2Cl2-PbO2 system (0-20 deg C, 1-3 h) yields 1,2,3,4-tetraaryl-2-butene-1,4-diones.According to (1)H NMR and GC-MS data the compounds synthesized have Z configuration.
