15258-01-2

Usage

Uses

Used in Pharmaceutical Industry:
(2-Chloroethyl)-4-fluorobenzamide is used as a precursor in the synthesis of bioactive compounds for its potential anti-cancer and anti-inflammatory properties. The presence of the chloroethyl group makes it a valuable building block for creating new pharmaceutical agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (2-chloroethyl)-4-fluorobenzamide serves as a subject of study for understanding its anti-cancer and anti-inflammatory mechanisms, which can contribute to the development of novel therapeutic agents.

InChI:InChI=1/C9H9ClFNO/c10-5-6-12-9(13)7-1-3-8(11)4-2-7/h1-4H,5-6H2,(H,12,13)

Upstream product

• 870-24-6 2-chloroethanamine hydrochloride 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 159671-82-6 N-(2-(4-Benzylpiperazin-1-yl)ethyl)-4-fluorobenzamide 
• 187221-43-8 4-Fluoro-N-(2-piperazin-1-yl-ethyl)-benzamide 
• 914306-63-1 N-(2,3,4,5,6-pentamethylbenzene)-2-(4-fluorophenyl)imidazolidine 
• 914400-75-2 N-(2,4,6-tribromophenyl)-2-(4-fluorophenyl)imidazoline 

Relevant academic research and scientific papers

N-vinyl amide and preparation method thereof

The invention relates to N-vinyl amide and a preparation method thereof. The preparation method comprises the following concrete steps: in the presence of triethylamine, reacting acyl chloride with 2-chloroethylamine hydrochloride to obtain corresponding N-(2-chloroethyl)amide, treating the N-(2-chloroethyl)amide with lithium diisopropylamide at room temperature, then adding halogenated hydrocarbon, carrying out a stirring reaction at room temperature for 4 hours, removing the solvent, and performing purification to obtain an N-vinyl amide compound. The preparation method of the invention is simple in synthetic route and uses easily-available raw materials; and the prepared N-vinyl amide compound is a good synthetic intermediate, and has potential biological activity and good application value.

IMPROVED STABILITY OLED MATERIALS AND DEVICES

Organic light emitting materials and devices comprising phosphorescent metal complexes comprising ligands comprising aryl or heteroaryl groups substituted at both ortho positions are described. An organic light emitting device, comprising: an anode; a hole transport layer; an organic emissive layer comprising an emissive layer host and an emissive dopant; an electron impeding layer; an electron transport layer; and a cathode disposed, in that order, over a substrate.

STABILITY OLED MATERIALS AND DEVICES WITH IMPROVED STABILITY

Organic light emitting materials and devices comprising phosphorescent metal complexes comprising ligands comprising aryl or heteroaryl groups substituted at both ortho positions are described. An organic light emitting device, comprising: an anode; a hole transport layer; an organic emissive layer comprising an emissive layer host and an emissive dopant; an electron impeding layer; an electron transport layer; and a cathode disposed, in that order, over a substrate.

New benzocycloalkylpiperazines, potent and selective 5-HT(1A) receptor ligands

A series of 1-(benzocycloalkyl)-4-(benzamidoalkyl)piperazine derivatives was prepared in order to obtain compounds with a high affinity and selectivity for 5-HT(1A) receptors. The modifications of aromatic substituents, the length of the alkyl chain, and the size of the ring were explored. Most of N-(1,2,3,4-tetrahydronaphthyl)-N'- (benzamidoethyl)piperazines (32-37) were bound to 5-HT(1A) receptors in a nanomolar range and presented a high degree of selectivity. After resolution, levorotatory enantiomers showed affinity and selectivity higher than those of dextrorotatory ones for 5-HT(1A) sites. The agonist type activity of selected derivatives was also confirmed in vitro on the inhibition of the activation of adenylate cyclase induced by forskolin and, in vivo, on the induction of the lower lip retraction in rats.