15258-55-6

Basic information

• Product Name: 2,3,4-TRIMETHOXYBENZALDEHYDE OXIME
• Synonyms: 2,3,4-TRIMETHOXYBENZALDEHYDE OXIME;2,3,4-TRIMETHOXYBENZALDOXIME;Einecs 239-298-4;(NE)-N-[(2,3,4-trimethoxyphenyl)methylidene]hydroxylamine
• CAS NO: 15258-55-6
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.21
• EINECS: 239-298-4
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 15258-55-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 321.5°Cat760mmHg
• Flash Point: 148.2°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.000123mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 2,3,4-TRIMETHOXYBENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-TRIMETHOXYBENZALDEHYDE OXIME(15258-55-6)
• EPA Substance Registry System: 2,3,4-TRIMETHOXYBENZALDEHYDE OXIME(15258-55-6)

Safety Data

• Hazardous Substances Data: 15258-55-6(Hazardous Substances Data)

Usage

Description

2,3,4-Trimethoxybenzaldehyde oxime is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a derivative of the aldehyde group, containing three methoxy groups attached to the benzene ring. 2,3,4-TRIMETHOXYBENZALDEHYDE OXIME is known for its ability to form stable complexes with metal ions, making it useful in the chelation and extraction of metal compounds. It also has potential applications as a chelating agent in analytical chemistry and as a building block in the synthesis of various organic compounds. Additionally, 2,3,4-Trimethoxybenzaldehyde oxime is being studied for its potential medicinal properties, including antioxidant and antimicrobial effects.

Uses

Used in Organic Synthesis:
2,3,4-Trimethoxybenzaldehyde oxime is used as a building block for the synthesis of various organic compounds, contributing to the development of new chemical entities and materials.
Used in Pharmaceutical Research:
2,3,4-Trimethoxybenzaldehyde oxime is used as a chelating agent in pharmaceutical research, facilitating the chelation and extraction of metal compounds, which can be crucial for the development of new drugs and therapies.
Used in Analytical Chemistry:
2,3,4-Trimethoxybenzaldehyde oxime is used as a chelating agent in analytical chemistry, aiding in the separation and analysis of metal ions in various samples.
Used in Antioxidant Applications:
2,3,4-Trimethoxybenzaldehyde oxime is being studied for its potential antioxidant properties, which could be beneficial in the development of treatments for various diseases and conditions associated with oxidative stress.
Used in Antimicrobial Applications:
2,3,4-Trimethoxybenzaldehyde oxime is being investigated for its potential antimicrobial effects, which could lead to the development of new antimicrobial agents and treatments for infectious diseases.

InChI:InChI=1/C10H13NO4/c1-13-8-5-4-7(6-11-12)9(14-2)10(8)15-3/h4-6,12H,1-3H3

Upstream product

• 634-36-6 1,2,3-trimethoxybenzene 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 1000854-02-3 C₁₀H₁₅NO₃*ClH 

Relevant articles and documents

HCl-mediated cascade cyclocondensation of oxygenated arylacetic acids with arylaldehydes: one-pot synthesis of 1-arylisoquinolines

In this paper, a concise, open-vessel synthesis of 1-arylisoquinolines is describedviaHCl-mediated intermolecular cyclocondensation of oxygenated arylacetic acids with arylaldehydes in the presence of NH2OH and alcoholic solvents under mild and one-pot reaction conditions. A plausible mechanism is proposed and discussed herein. In the overall reaction process, only water was generated as the byproduct. Various environmentally friendly reaction conditions are investigated for convenient transformationviathe (4C + 1C + 1N) annulation. This protocol provides a highly effective ring closureviathe formations of one carbon-carbon (C-C) bond, two carbon-nitrogen (C-N) bonds and one carbon-oxygen (C-O) bond.

Efficient transformation of electron-rich arenes into diethyl 3-arylisoxazole-4,5-dicarboxylates

Treatment of electron-rich arenes with Tf2O and DMF, followed by the reaction with NH2OH·HCl and then with Oxone in the presence of diethyl acetylenedicarboxylate generated diethyl 3-arylisoxazole-4,5-dicarboxylates in good to modera

Continuous Platform to Generate Nitroalkanes On-Demand (in Situ) Using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

The synthetic utility of the aza-Henry reaction can be diminished on scale by potential hazards associated with the use of peracid to prepare nitroalkane substrates and the nitroalkanes themselves. In response, a continuous and scalable chemistry platform to prepare aliphatic nitroalkanes on-demand using the oxidation of oximes with peracetic acid and direct reaction of the nitroalkane intermediate in an aza-Henry reaction is reported. A uniquely designed pipes-in-series plug-flow tube reactor addresses a range of process challenges, including stability and safe handling of peroxides and nitroalkanes. The subsequent continuous extraction generates a solution of purified nitroalkane, which can be directly used in the following enantioselective aza-Henry chemistry to furnish valuable chiral diamine precursors with high selectivity, thus completely avoiding isolation of the potentially unsafe low-molecular-weight nitroalkane intermediate. A continuous campaign (16 h) established that these conditions were effective in processing 100 g of the oxime and furnishing 1.4 L of nitroalkane solution.