15265-22-2Relevant articles and documents
Stabilisation of peptide foldamers in an aqueous medium by incorporation of azapeptide building blocks
Hetenyi, Anasztazia,Toth, Gabor K.,Somlai, Csaba,Vass, Elemer,Martinek, Tamas A.,Fueloep, Ferenc
, p. 10736 - 10741 (2009)
Stable foldamers in water: Helical peptidic foldamers including H12 and H10/12 helices were constructed and stabilised in water. The foldamers' extra rigidity stems from the strong hydrogen bonding network of the azapeptide groups (see graphic).
ORALLY EFFECTIVE ANTI-HYPERTENSIVE AGENTS
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, (2008/06/13)
Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula, EQU1 wherein Z denotes-B-A 2, R 1 is H or an acyl group, A 1 is a carboxylic acid containing at least one amino or imino-N-, A 2 is a carboxylic acid containing at least one amino or imino-N-or a lower alkyl ester or amide thereof, B is a 2-4 carbon backbone chain in mercapto linkage to S which includes a carbonyl or sulfonyl group joined in carboxamido or sulfonamido linkage, respectively, to A 2. Preferably A 2 includes a 4-6 membered C-N ring or a 5 membered ring of one N, one S and 3 C atoms.
MERCAPTOACYLAMINO DERIVATIVES OF HETROCYCLIC CARBOXYLIC ACIDS
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, (2008/06/13)
New mercaptoacyl derivatives of heterocyclic carboxylic acids which have the general formula STR1 are useful as angiotensin converting enzyme inhibitors.
