15266-82-7

Basic information

• Product Name: 3-phenethylpiperazine-2,5-dione
• Synonyms: 3-phenethylpiperazine-2,5-dione
• CAS NO: 15266-82-7
• Molecular Weight: 218.255
• Mol File: 15266-82-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-phenethylpiperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenethylpiperazine-2,5-dione(15266-82-7)
• EPA Substance Registry System: 3-phenethylpiperazine-2,5-dione(15266-82-7)

Safety Data

• Hazardous Substances Data: 15266-82-7(Hazardous Substances Data)

Upstream product

• 7064-04-2 ethyl 5-phenyl-2-isoxazoline-3-carboxylate 
• 10313-27-6 5-phenyl-4,5-dihydroisoxazole-3-carboxylic acid 
• 100-42-5 styrene 

Relevant articles and documents

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

We report here on the use of ethyl nitroacetate as a glycine template to produce α-amino esters. This started with a study of its condensation with various arylacetals to give ethyl 3-aryl-2-nitroacrylates followed by a reduction (NaBH4 and then zinc/HCl) into α-amino esters. The scope of this method was explored as well as an alternative with arylacylals instead. We also focused on various [2 + 3] cycloadditions, one leading to a spiroacetal, which led to the undesired ethyl 5-(benzamidomethyl)isoxazole-3-carboxylate. The addition of ethyl nitroacetate on a 5-methylene-4,5-dihydrooxazole using cerium(IV) ammonium nitrate was also explored and the synthesis of other oxazole-bearing α-amino esters was achieved using gold(I) chemistry.