15267-39-7

Upstream product

• 2574-25-6 Diisopropyl chlorophosphate 
• 106-54-7 p-Chlorothiophenol 
• 116-17-6 triisopropyl phosphite 
• 1809-20-7 diisopropyl hydrogenphosphonate 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 10533-37-6 potassium O,O-diisopropyl phoshorodithioate 

Relevant academic research and scientific papers

Cu(II)/Proline-Catalyzed Reductive Coupling of Sulfuryl Chloride and P(O)-H for P-S-C Bond Formation

A considerably improved method for the Cu-catalyzed coupling of sulfuryl chloride with P(O)-H was described. Using commercially available l-proline as the ligand decreased the precatalyst loading, broadened the substrate scope and greatly promoted the efficiency of the coupling reaction. Moreover, gram-scale preparation, easy-to handle and recyclable catalyst featured this transformation.

K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols

Convenient, practical and economical phosphorylation of thiols has been achieved via halogen- and metal-free K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites, dimethyl phenylphosphonite, or methyl diphenylphosphinite with thiophenols using air as the oxidant at room temperature. This transformation provides a straightforward route to the construction of phosphorus-sulfur bonds with wide functional group compatibility, which affords phosphorothioates in up to 94% yield.

Cs2CO3-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Thiols with Phosphonates and Arenes

An efficient Cs2CO3-catalyzed oxidative coupling of thiols with phosphonates and arenes that uses molecular oxygen as the oxidant is described. These reactions provide not only a novel alkali metal salt catalyzed aerobic oxidation, but also an efficient approach to thiophosphates and sulfenylarenes, which are ubiquitously found in pharmaceuticals and pesticides. The reaction proceeds under simple and mild reaction conditions, tolerates a wide range of functional groups, and is applicable to the late-stage synthesis and modification of bioactive molecules.

A thiophosphate synthetic method of compound and the method in a plurality of pharmaceutical application in the synthesis of (by machine translation)

The invention discloses a having the general formula (III) of the thiophosphate synthetic method of compound, the purpose is to provide a novel, condition is simple, easy to industrial production of the thiophosphate synthetic method of compound. The method is to have the general formula (I) of the organophosphorus oxygen apperception compound having the general formula (II) with a mercaptan or phenyl-sulfhydryl apperception compound mixed, under the effects of catalyst, obtained by the reaction of the formula (III) of the thiophosphate compound. The method of the invention, can be cheap efficient synthesis of thiophosphate compounds, in actual production will have extensive application prospect. (by machine translation)

Phosphorothioate-mercaptophosphonate rearrangement: Synthesis of new o-mercaptoaryl-and omercaptoheteroaryl phosphonates and their derivatives

New o-mercaptoaryl and o-mcrcaptohetcroaryl phosphonates and their derivatives were prepared via an ori/io-lithiation of O,O-diisopropyl S-aryl, 5-(2-pyridyl), S-(2-thienyl) and 5-(3-thienyl) phosphorothioates followed by a phosphonyl group S → C migration. Elsevier,.

Hypervalent Iodine in Synthesis: 12. A New and Convenient Method for Preparation of O,O-Dialkyl S-Aryl Phosphoro Thiolates

O,O-Dialkyl S-aryl phosphorothiolates have been prepared in better yields by the reaction of diaryliodonium salts with potassium O,O-dialkyl phosphorothiolates in cyclohexane at reflux temperature.