15267-80-8

Basic information

• Product Name: 2-(4-methoxyphenoxy)acetohydroxamic acid
• Synonyms: 2-(4-methoxyphenoxy)acetohydroxamic acid
• CAS NO: 15267-80-8
• Molecular Weight: 197.191
• Mol File: 15267-80-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenoxy)acetohydroxamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxy)acetohydroxamic acid(15267-80-8)
• EPA Substance Registry System: 2-(4-methoxyphenoxy)acetohydroxamic acid(15267-80-8)

Safety Data

• Hazardous Substances Data: 15267-80-8(Hazardous Substances Data)

Upstream product

• 18598-23-7 ethyl (4-methoxyphenoxy)acetate 
• 150-76-5 4-methoxy-phenol 

Relevant articles and documents

The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections

Two series of ω-phenoxy contained acylhydroxamic acids as novel urease inhibitors were designed and synthesized. Biological activity evaluations revealed that ω-phenoxypropinoylhydroxamic acids were more active than phenoxyacetohydroxamic acids. Out of these compounds, 3-(3,4-dichlorophenoxy)propionylhydroxamic acid c24 showed significant potency against urease in both cell free extract (IC50 = 0.061 ± 0.003 μM) and intact cell (IC50 = 0.89 ± 0.05 μM), being over 450- and 120-fold more potent than the clinically prescribed urease inhibitor AHA, repectively. Non-linear fitting of experimental data (V-[S]) suggested a mixed-type inhibition mechanism and a dual site binding mode of these compounds.