18598-23-7

Basic information

• Product Name: (4-METHOXYPHENOXY) ACETIC ACID ETHYL ESTER
• Synonyms: TIMTEC-BB SBB009262;(4-METHOXYPHENOXY) ACETIC ACID ETHYL ESTER;AKOS B006639;ART-CHEM-BB B006639
• CAS NO: 18598-23-7
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol File: 18598-23-7.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 297.8°Cat760mmHg
• Flash Point: 128.3°C
• Appearance: /
• Density: 1.103g/cm³
• Vapor Pressure: 0.00132mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: (4-METHOXYPHENOXY) ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHOXYPHENOXY) ACETIC ACID ETHYL ESTER(18598-23-7)
• EPA Substance Registry System: (4-METHOXYPHENOXY) ACETIC ACID ETHYL ESTER(18598-23-7)

Safety Data

• Hazardous Substances Data: 18598-23-7(Hazardous Substances Data)

Usage

General Description

(4-Methoxyphenoxy) acetic acid ethyl ester, also known as ethyl (4-methoxyphenoxy)acetate, is a chemical compound with the molecular formula C11H14O4. It is commonly used as a solvent or a chemical intermediate in organic synthesis. (4-METHOXYPHENOXY) ACETIC ACID ETHYL ESTER is a clear, colorless liquid with a faint aromatic odor and is slightly soluble in water but more soluble in organic solvents. It is often used in the production of pharmaceuticals, pesticides, and other organic compounds. While it is not typically considered to be highly toxic, it should be handled with care and used in a well-ventilated area due to its potential to cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C11H14O4/c1-3-14-11(12)8-15-10-6-4-9(13-2)5-7-10/h4-7H,3,8H2,1-2H3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 150-78-7 1,4-dimethoxybezene 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 
• 105-39-5 chloroacetic acid ethyl ester 
• 150-76-5 4-methoxy-phenol 
• 105-36-2 ethyl bromoacetate 
• 64-17-5 ethanol 
• 79-11-8 chloroacetic acid 
• 1122-95-8 sodium 4-methoxyphenolate 

Downstream Products

• 854630-90-3 4-(4-methoxy-phenoxy)-2-phenyl-acetoacetonitrile 
• 1227-61-8 mefexamide 
• 15267-80-8 2-(4-methoxyphenoxy)acetohydroxamic acid 
• 159622-29-4 4-(4-methoxyphenoxy)-3-oxo-butanoic acid ethyl ester 
• 159622-34-1 (S)-3-hydroxy-4-(4-methoxyphenoxy)-butanoic acid 
• 181027-16-7 3-Hydroxy-4-(4-methoxy-phenoxy)-butyric acid ethyl ester 
• 181027-19-0 3-Hydroxy-4-(4-methoxy-phenoxy)-butyric acid methyl ester 
• 815627-04-4 1-(4-methoxy-phenoxy)-3-phenyl-acetone 
• 854633-58-2 4-(4-methoxy-phenoxy)-2-phenyl-acetoacetic acid amide 

Relevant articles and documents

Fluorescent DNA-poly(phenylenevinylene) hybrid hydrogels for monitoring drug release

A new class of fluorescent DNA-poly(phenylenevinylene) hybrid hydrogels (DNA/SP-PPV) have been prepared by in situ polymerization of monomer with salmon DNA as template, which are used for monitoring drug release driven by media pH. The Royal Society of Chemistry 2009.

Recognition selectivities of lasso-type pseudo[1]rotaxane based on a mono-ester-functionalized pillar[5]arene

Two types of mono-ester-functionalized pillar[5]arenes, P1 and P2, bearing different side-chain groups, were synthesized. Their host–guest complexation and self-inclusion properties were studied by 1H NMR and 2D nuclear overhauser effect spectr

Copillar[5]arene-rhodamine conjugate as a selective sensor for Hg2+ ions

A new copillar[5]arene coupled rhodamine probe 1 has been designed and synthesized. The molecular probe shows selective sensing of Hg2+ ions over a series of metal ions in CH3CN by exhibiting a color change of the solution as well as

Identification and synthesis of selective cholesterol esterase inhibitor using dynamic combinatorial chemistry

In this study, the concept of dynamic combinatorial chemistry (DCC) was applied to explore novel cholesterol esterase (CEase) inhibitors. In the presence of enzyme, two substrates (A1H3 and A2H3) were amplified from the dynamic combinatorial library (DCL), which was generated through reversible acylhydrazone formation reaction. In the in vitro biological evaluation, compound A1H3 exhibited not only potent (IC50 in nanomolar range) but also selective inhibition (>120 folds of selectivity for CEase over AChE). Furthermore, the binding pattern and possible binding mechanism were investigated in the kinetic experiment and molecular docking study, respectively.

Design, synthesis and molecular modelling of phenoxyacetohydrazide derivatives as Staphylococcus aureus MurD inhibitors

In the present work we synthesized a new series of phenoxyacetohydrazide functional compounds 4a-k and characterized by spectral data. Synthesized compounds were screened in vitro for their antibacterial activity. Compounds 4a, 4j and 4k exhibited inhibitory activity against S. aureus NCIM 5022 with MIC value of 64?μg/ml These compounds also exhibited activity against methicillin resistant S. aureus ATCC 43300 with MIC of 128?μg/ml. Among all the tested compounds 4c and 4j showed highest activity, respectively against B. subtilis NCIM 2545 and K. pneumoniae NCIM 2706. Only one compound i.e. 4d showed activity against another Gram-negative bacteria P. aeruginosa NCIM 2036 with MIC value of 64?μg/ml. Among three tested compounds, 4k exhibited highest inhibitory activity against S. aureus MurD enzyme with IC50 value of 35.80?μM. Further binding interactions of 4a-k with the modelled S. aureus MurD catalytic pocket residues is investigated with the extra-precision molecular docking and binding free energy calculation by MM-GBSA approach. The van der Waals energy term was observed to be the driving force for binding. Further, 50?ns molecular dynamics simulations were performed to validate the stabilities of 4j- and 4k-modelled S. aureus MurD. Graphic abstract: [Figure not available: see fulltext.]

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.