1527-34-0

Basic information

• Product Name: DIETHYL(4-CARBOXYPHENYL)PHOSPHONATE
• Synonyms: DIETHYL(4-CARBOXYPHENYL)PHOSPHONATE;CHEMPACIFIC 60142;4-(DIETHOXY-PHOSPHORYL)-BENZOIC ACID;Diethyl(4-carboxyphenyl)phosphonate, 98 %;p-Phosphonobenzoic Acid P,P-Diethyl Ester;Benzoic acid, 4-(diethoxyphosphinyl)-
• CAS NO: 1527-34-0
• Molecular Formula: C₁₁H₁₅O₅P
• Molecular Weight: 258.21
• Product Categories: Aromatics;Chromatography Media;Phosphorylating and Phosphitylating Agents
• Mol File: 1527-34-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 105-107 °C
• Boiling Point: 382 °C at 760 mmHg
• Flash Point: 184.8 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 1.62E-06mmHg at 25°C
• Refractive Index: 1.514
• PKA: 3?+-.0.10(Predicted)
• CAS DataBase Reference: DIETHYL(4-CARBOXYPHENYL)PHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL(4-CARBOXYPHENYL)PHOSPHONATE(1527-34-0)
• EPA Substance Registry System: DIETHYL(4-CARBOXYPHENYL)PHOSPHONATE(1527-34-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1527-34-0(Hazardous Substances Data)

Usage

Uses

4-(Diethoxyphosphinyl)benzoic Acid is used as an analytical reagent used for enhanced chromatographic resolution of alcohol enantiomers as phosphonate derivatives.

InChI:InChI=1/C11H15O5P/c1-3-15-17(14,16-4-2)10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3,(H,12,13)

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 586-76-5 4-Bromobenzoic acid 
• 619-58-9 4-iodobenzoic acid 
• 17067-92-4 diethyl (4-ethoxycarbonylphenyl)phosphonate 
• 74-11-3 para-chlorobenzoic acid 
• 122-52-1 triethyl phosphite 

Downstream Products

• 618-21-3 4-phosphonbenzoic acid 

Relevant articles and documents

Palladium-catalyzed one-pot phosphorylation of phenols mediated by sulfuryl fluoride

We report a general palladium-catalyzed one-pot procedure for the synthesis of phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride. It features mild conditions, broad substrate scope, high functionality tolerance and water insensitivity. The utility of this procedure has been well demonstrated by gram-scale synthesis, sequential synthesis of click chemistry building blocks, late-stage decoration of drugs and natural products and on-DNA synthesis of phosphine oxide for a DNA-encoded library (DEL).

Peptide analogues and uses thereof

This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RG and Z are as defined herein, and to their preparation and use.

Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof

The invention relates to compounds of the general formula: in which RA-RC and W are as defined herein, and to their preparation and use.