1527-34-0

Usage

Uses

Used in Analytical Chemistry:
DIETHYL(4-CARBOXYPHENYL)PHOSPHONATE is used as an analytical reagent for enhanced chromatographic resolution of alcohol enantiomers as phosphonate derivatives. This application is particularly useful in the field of pharmaceuticals and organic chemistry, where the separation and identification of chiral compounds are crucial for understanding their properties and potential applications.

InChI:InChI=1/C11H15O5P/c1-3-15-17(14,16-4-2)10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3,(H,12,13)

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 74-11-3 para-chlorobenzoic acid 
• 122-52-1 triethyl phosphite 
• 586-76-5 4-Bromobenzoic acid 
• 17067-92-4 diethyl (4-ethoxycarbonylphenyl)phosphonate 
• 619-58-9 4-iodobenzoic acid 

Downstream Products

• 618-21-3 4-phosphonbenzoic acid 

Relevant academic research and scientific papers

Palladium-catalyzed one-pot phosphorylation of phenols mediated by sulfuryl fluoride

We report a general palladium-catalyzed one-pot procedure for the synthesis of phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride. It features mild conditions, broad substrate scope, high functionality tolerance and water insensitivity. The utility of this procedure has been well demonstrated by gram-scale synthesis, sequential synthesis of click chemistry building blocks, late-stage decoration of drugs and natural products and on-DNA synthesis of phosphine oxide for a DNA-encoded library (DEL).

Synthesis and antibacterial activity of new aryl / alkyl phosphonates via Michaelis-Arbuzov rearrangement

Synthesis of new aryl / alkyl phosphonates 3a-j has been accomplished via a Michaelis- Arbuzov-type rearrangement by the reaction of aryl / alkyl halide (1a-j) with triethyl phosphite (2) in dry toluene at reflux temperature. Products 3a-j were characterized by IR, 13C and 31P NMR and their antibacterial activity was evaluated.

Peptide analogues and uses thereof

This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RG and Z are as defined herein, and to their preparation and use.

Novel pyridopyrimidones and uses thereof

This invention relates to compounds of the general formula: in which RA, RB and RC are as defined herein, and to their preparation and use.

Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof

The invention relates to compounds of the general formula: in which RA-RC and W are as defined herein, and to their preparation and use.

Novel indolinones and uses thereof

This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RE, p, q and X are as defined herein, and to their preparation and use.

Novel quinolinones and uses thereof

The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): 1in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q,

Novel quinolines and uses thereof

This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.

Novel quinazolines and uses thereof

This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.

Enhanced chromatographic resolution of alcohol enantiomers as phosphate or phosphonate derivatives

Phosphate and phosphonate derivatives of chiral alcohols show enhanced resolution by HPLC using a chiral support. Labile derivatives were also prepared that allow separation and recovery of the corresponding alcohol after basic hydrolysis.