152706-71-3Relevant academic research and scientific papers
Microwave assisted transformation of benzimidazolyl chalcones into N 1-substituted pyrazolines and evaluation of their antimicrobial activities
Rajora, Jayanti,Yadav, Janardan,Kumar, Ravindra,Srivastava, Yogendra K.
experimental part, p. 989 - 993 (2010/11/03)
1-Benzimidazolyl-3-aryl-prop-2-ene-1-ones 2 have been transformed into N1-substituted pyrazoline derivatives by the interaction with phenyl hydrazine, thiosemicarbazide and hydrazine hydrate in the presence of formic acid under solvent microwave induced protocol. The structure of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial activity in against E. coli, K. pneumonae, P. aeruginosa and B. subtilis using paper disc method. Some of the compounds have shown significant activity against the pathogens.
Pyrazoline bearing benzimidazoles: Search for anticancer agent
Shaharyar, Mohammad,Abdullah,Bakht,Majeed, Jaseela
experimental part, p. 114 - 119 (2010/03/30)
2-acetyl benzimidazole was allowed to react with substituted aromatic aldehydes to get desired intermediate chalcones (2a-g), the cyclocondensation of these intermediates with hydrazine hydrate and phenyl hydrazine in two separate reactions yielded pyrazoline derivatives (3a-g & 4a-g respectively). Among the synthesize compounds, six compounds were granted NSC code and screened at National Cancer Institute (NCI), USA for anticancer activity at a single high dose (10-5 M) in full NCI 60 cell panel. Among the selected compounds, (4f) 2-[5-(3,4-dimethoxyphenyl)-1-phenyl-4,5-dihydro-1H-3-pyrazolyl]-1H-benzimidazole (NSC 748326) was found to be the most active candidate of the series and selected for further evaluation at five dose level screening.
