1527503-11-2 Usage
Description
5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine is a complex organic compound with a unique molecular structure. It is characterized by its spiro-linked cyclobutane and indole rings, along with a methoxy and pyrrolidinylpropoxy functional groups. 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine holds potential for various applications due to its specific structural features and interactions with biological targets.
Uses
Used in Pharmaceutical Industry:
5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine is used as a potent peptide-competitive inhibitor for the lysine methyltransferase G9a. It exhibits a high degree of selectivity (1000 fold) over other methyl transferases, making it a valuable compound for the development of targeted therapies in the treatment of various diseases.
Used in Epigenetic Research:
In the field of epigenetics, this compound is utilized as a research tool to study the role of G9a in gene regulation and its implications in disease pathology. By inhibiting G9a, researchers can gain insights into the epigenetic mechanisms that underlie various biological processes and disorders.
Used in Drug Development:
5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine serves as a lead compound in the development of new drugs targeting G9a-mediated processes. Its high selectivity and potency make it an attractive candidate for further optimization and refinement to create more effective and safer therapeutic agents.
Biochem/physiol Actions
A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC50 values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Check Digit Verification of cas no
The CAS Registry Mumber 1527503-11-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,2,7,5,0 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1527503-11:
(9*1)+(8*5)+(7*2)+(6*7)+(5*5)+(4*0)+(3*3)+(2*1)+(1*1)=142
142 % 10 = 2
So 1527503-11-2 is a valid CAS Registry Number.
1527503-11-2Relevant articles and documents
INHIBITORS OF HISTONE METHYLTRANSFERASE G9a
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Paragraph 0208, (2015/12/23)
Described herein are compounds, pharmaceutical compositions and methods for treating cancer, inflammation, or autoimmune disease in a subject, or for inhibiting histone methyltransferase G9a.
