152797-10-9Relevant academic research and scientific papers
Rearrangement of tosyl group of 3,4-disubstituted 2-tosylpyrroles under mild acidic conditions
Kohori, Kazuhiro,Kinoshita, Hideki,Inomata, Katsuhiko
, p. 799 - 800 (1995)
Tosyl group of 3,4-disubstituted 2-tosylpyrroles easily rearranged from 2- to 5- position by treatment with TFA.The ratio of the regioisomers at equilibrium was definitely influenced by the bulkiness of the substituent at 3-position of starting 2-tosylpyrroles.
Convenient and Regioselective Syntheses of 3,4-Disubstituted Δ3-Pyrrolin-2-ones Derivatives Starting from 2-Tosyl-3,4-Disubstituted Pyrroles
Kinoshita, Hideki,Hayashi, Yoshio,Murata, Yasue,Inomata, Katsuhiko
, p. 1437 - 1440 (2007/10/02)
3,4-Disubstituted Δ3-pyrrolin-2-ones were prepared in high yields via 5-tosyl-Δ3-pyrrolin-2-ones (4) starting from 2-tosylpyrroles regioselectively.The compounds 4 were found to be useful intermediates for the preparation of variety of Δ3-pyrrolin-2-one derivatives.The reactions of 4 with various nucleophiles and active methylene compounds bearing an appropriate leaving group are described.
