152832-96-7Relevant academic research and scientific papers
Synthesis and preliminary biological evaluation of O6-[4-(2- [18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in cancer chemotherapy
Wang, Ji-Quan,Kreklau, Emiko L.,Bailey, Barbara J.,Erickson, Leonard C.,Zheng, Qi-Huang
, p. 5779 - 5786 (2005)
A novel fluorine-18-labeled O6-benzylguanine (O6-BG) derivative, O6-[4-(2-[18F]fluoroethoxymethyl)benzyl] guanine (O6-[18F]FEMBG, [18F]1), has been synthesized for evaluation as
Synthesis and Preliminary Biological Evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, New Potential PET Breast Cancer Imaging Agents for the DNA Pepair Protein AGT
Liu, Xuan,Zheng, Qi-Huang,Fei, Xiangshu,Wang, Ji-Quan,Ohannesian, David W.,Erickson, Leonard C.,Stone, K. Lee,Hutchins, Gary D.
, p. 641 - 644 (2007/10/03)
Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase
Chae,McDougall,Dolan,Swenn,Pegg,Moschel
, p. 342 - 347 (2007/10/02)
Several new O6-benzylguanine analogs bearing increasingly bulky substituent groups on the benzene ring or at position 9 were tested for their ability to inactivate the human DNA repair protein, O6-alkylguanine-DNA alkyltransferase. S
