15285-58-2 Usage
Uses
Used in Pharmaceutical Industry:
4-AZONIASPIRO[3.5]NONANE, 2-HYDROXY-,CHLORIDE is used as a reagent for the synthesis of Arimoclomol Maleic Acid (A771270), an orally administered drug for the treatment of amyotrophic lateral sclerosis. 4-AZONIASPIRO[3.5]NONANE, 2-HYDROXY-,CHLORIDE plays a crucial role in the development of therapeutic agents for this neurodegenerative disease.
Used in Chemical Synthesis:
4-AZONIASPIRO[3.5]NONANE, 2-HYDROXY-,CHLORIDE is used as a reagent in the synthesis of polyfunctional phosphorodithioates and its derivatives via nucleophilic ring opening of azetidinium ions. This application highlights its importance in the creation of complex chemical structures with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 15285-58-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,8 and 5 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 15285-58:
(7*1)+(6*5)+(5*2)+(4*8)+(3*5)+(2*5)+(1*8)=112
112 % 10 = 2
So 15285-58-2 is a valid CAS Registry Number.
15285-58-2Relevant academic research and scientific papers
Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives
Atkinson, Benjamin N.,Woodward, Hannah L.,Sipthorp, James,Fish, Paul V.
, p. 9794 - 9799 (2017/12/12)
A new efficient chiral synthesis of enantiopure arimoclomol (2) is reported from (R)-(-)-glycidyl nosylate (11) with complete retention of chiral integrity. Off-target pharmacology of arimoclomol (2) was evaluated against a representative set of drug targets and showed modest binding to a few kinases. Pharmacokinetic data was generated in vivo in mouse and showed a low brain:plasma ratio. These studies will be helpful towards a better understanding of the PK-PD relationship of 2 in disease models.
Synthesis and pharmacological properties of new derivatives of 4-alkoxy-6-methyl-1h-pyrrolo[3,4-c]pyridine- 1,3(2h)-diones
Sladowska, Helena,Sabiniarz, Aleksandra,Sapa, Jacek,Filipek, Barbara
body text, p. 57 - 63 (2009/06/17)
Synthesis of 2-(2-hydroxy-3-amino)propyl derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones (24-35) is described. The chlorides used in the above synthesis exist mainly in the cyclic forms (18, 20-23). Only chloride with benzhydryl
