15286-45-0

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 100-01-6 4-nitro-aniline 
• 104-55-2 3-phenyl-propenal 

Downstream Products

• 131480-03-0 diethyl 1-(4-nitrophenylamino)-3-phenylprop-2-enephosphonate 
• 501680-99-5 4-nitro-N-(3-phenylpropyl)aniline 
• 91462-44-1 1-(4-Nitro-phenyl)-4-phenyl-3,4-dihydro-1H-pyridin-2-one 
• 1609261-91-7 1-(4-bromophenyl)-3-(4-nitrophenyl)-6-oxo-2-styryl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylic acid dimethyl ester 
• 145825-95-2 1-Biphenyl-4-yl-2-[4-phenyl-4H-[1,3]dithiin-(2E)-ylidene]-ethanone 
• 106724-48-5 4-Cyclohept-1-enyl-1-(4-nitro-phenyl)-5-((E)-styryl)-1H-imidazole 
• 106724-46-3 4-Cyclohex-1-enyl-1-(4-nitro-phenyl)-5-((E)-styryl)-1H-imidazole 
• 106724-45-2 4-Cyclopent-1-enyl-1-(4-nitro-phenyl)-5-((E)-styryl)-1H-imidazole 

Relevant academic research and scientific papers

Synthesis of β-Phosphinolactams from Phosphenes and Imines

Various cis-β-phosphinolactams are synthesized stereoselectively for the first time from imines and diazo(aryl)methyl(diaryl)phosphine oxides under microwave irradiation. Diazo(aryl)methyl(diaryl)phosphine oxides first undergo the Wolf rearrangement to generate phosphenes. Imines nucleophilically attack the phosphenes followed by an intramolecular nucleophilic addition via less steric transition states to give final cis-β-phosphinolactams. C-Styrylimines generally give rise to β-phosphinolactams in higher yields than C-arylimines. The stereoselectivity and proposed mechanism are rationalized by DFT theoretical calculation.

Antileishmanial, antimicrobial and antifungal activities of some new aryl azomethines

A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed.

Polymethylhydrosiloxane (PMHS)/trifluoroacetic acid (TFA): a novel system for reductive amination reactions

Polymethylhydrosiloxane (PMHS)/trifluoroacetic acid (TFA) was discovered as a novel metal-free system for reductive amination reactions. A variety of (het)aryl amines as well as a representative carbamate and urea were successfully alkylated by benzaldehyde in the presence of PMHS and TFA in dichloromethane at room temperature in moderate to excellent yields (28-87%). Furthermore, this reaction protocol was successfully applied to the alkylation of p-nitroaniline with a wide range of aldehydes, ketones, and a representative acetal to obtain the alkylated products in yields ranging from 40% to 92%. The current work represents one of the very few examples of PMHS being activated by a Br?nsted acid.

Synthesis of organophosphorus compounds via silyl esters of phosphorous acids

The addition of trimethylsilyloxy phosphorus (III)derivatives generated in situ to imines at room temperature provides a mild selective and high yielding route to α-aminoalkylphosphorate and α-aminoalkylphenylphosphinate esters. Isocyanates and carbodiimides react similarly to give phosphonoureas and phosphonoguarnidines respectively aldehydes and ketones are much less reactive and cyanides are inert.