152971-88-5

Basic information

• Product Name: Isoquinoline, 1,2,3,4-tetrahydro-1-(1-methylethyl)-, (S)- (9CI)
• Synonyms: Isoquinoline, 1,2,3,4-tetrahydro-1-(1-methylethyl)-, (S)- (9CI);(S)-1-Isopropyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 152971-88-5
• Molecular Formula: C12H17N
• Molecular Weight: 175.27008
• Product Categories: ISOPROPYL
• Mol File: 152971-88-5.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Isoquinoline, 1,2,3,4-tetrahydro-1-(1-methylethyl)-, (S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1,2,3,4-tetrahydro-1-(1-methylethyl)-, (S)- (9CI)(152971-88-5)
• EPA Substance Registry System: Isoquinoline, 1,2,3,4-tetrahydro-1-(1-methylethyl)-, (S)- (9CI)(152971-88-5)

Safety Data

• Hazardous Substances Data: 152971-88-5(Hazardous Substances Data)

Upstream product

• 71611-83-1 1-isopropyl-3,4-dihydroisoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 20922-03-6 1-(propan-2-yl)isoquinoline 
• 77796-20-4 1-isopropyl-1,2,3,4-tetrahydroisoquinoline 
• 64-04-0 phenethylamine 
• 71022-62-3 2-methyl-N-(2′-phenethyl)-propionamide 
• 1068-55-9 isopropylmagnesium chloride 
• 76068-81-0 1-(3,4-dihydroisoquinolin-2(1H)-yl)-2,2-dimethylpropan-1-one 
• 78702-53-1 2-bis(dimethylamino)phosphinoyl-1,2,3,4-tetrahydroisoquinoline 
• 103-63-9 1-phenyl-2-bromoethane 
• 927406-87-9 2-(4,5-dihydro-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline 
• 85838-87-5 N-(2-methylpropylidene)benzeneethanamine 
• 164020-61-5 2-bromo-N-(2-methylpropylidene)benzeneethanamine 
• 142387-75-5 [2-(2-Bromo-phenyl)-ethyl]-[2-methyl-prop-(E)-ylidene]-amine 

Downstream Products

• 1721-93-3 1-methylisoquinoline 
• 20922-03-6 1-(propan-2-yl)isoquinoline 
• 4965-09-7 1-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

A through halogen bond activation isoquinoline asymmetric hydrogenation method

A through halogen bond activation isoquinoline asymmetric hydrogenation method, the catalyzing system is [...] complex, the activator is a halide. The reaction can be carried out under the following conditions, temperature: 25 - 100 °C; solvent: tetrahydr

Dual Stereocontrol for Enantioselective Hydrogenation of Dihydroisoquinolines Induced by Tuning the Amount of N-Bromosuccinimide

An efficient dual stereocontrol in iridium-catalyzed hydrogenation of 1-substituted 3,4-dihydroisoquinolines was realized by tuning the amount of N-bromosuccinimide using chiral ligand of single configuration, providing both enantiomers of 1-substituted 1,2,3,4-tetrahydroisoquinolines with up to 89% ee (S) and 98% ee (R), respectively. Dual activation role of N-bromosuccinimide is proposed to be responsible for the reversal of enantioselectivity under two hydrogenation conditions.

Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator

By employing halogenide trichloroisocyanuric acid as a traceless activation reagent, a general iridium-catalyzed asymmetric hydrogenation of isoquinolines and pyridines is developed with up to 99% ee. This method avoids tedious steps of installation and removal of the activating groups. The mechanism studies indicated that hydrogen halide generated in situ acted as an activator of isoquinolines and pyridines.