4965-09-7

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-1,2,3,4-tetrahydroisoquinoline is used as an antidepressant agent for its neuroprotective activity and ability to produce antidepressant-like effects similar to imipramine. It acts as a reversible short-acting moderate inhibitor of MAO A/B, contributing to its therapeutic potential in treating depression and related disorders.
Additionally, it is used as a parkinsonism-preventing substance, offering potential benefits in the management and prevention of Parkinson's disease.
Used as an Intermediate in Drug Development:
1-Methyl-1,2,3,4-tetrahydroisoquinoline serves as a crucial intermediate in the synthesis of revaprazan, a pharmaceutical compound with therapeutic applications. Its role in the development of new drugs highlights its importance in the pharmaceutical industry.

InChI:InChI=1/C10H13N/c1-8-10-5-3-2-4-9(10)6-7-11-8/h2-5,8,11H,6-7H2,1H3

Upstream product

• 64982-61-2 (S)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 64-04-0 phenethylamine 
• 2412-58-0 1-methyl-3,4,dihydroisoquinoline 
• 77796-20-4 1-isopropyl-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 198883-93-1 N-benzoyl-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 178307-42-1 Revaprazan hydrochloride 
• 84010-66-2 (R)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 64982-61-2 (S)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1346681-98-8 (1S)-2-(3-mesitylpropanoyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1721-93-3 1-methylisoquinoline 
• 2412-58-0 1-methyl-3,4,dihydroisoquinoline 
• 178307-42-1 revaprazan hydrochloride 
• 27694-87-7 nona-1,2-dien-1-ylbenzene 
• 14429-09-5 N-methyl-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 140381-73-3 N-(2-nitrophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Acceptorless dehydrogenation of nitrogen heterocycles with a versatile iridium catalyst

Gas up: A cyclometalated iridium complex is found to catalyze the dehydrogenation of various benzofused N-heterocycles, thus releasing H 2. Driven by as low as 0.1 mol % catalyst, the reaction affords quinolines, indoles, quinoxalines, isoquinolines, and β-carbolines in high yields. Copyright

Chemoenzymatic dynamic kinetic resolution of secondary amines

The kinetic resolution of amines using a novel iridium based catalyst coupled with an enzyme catalysed step is achieved on a large scale with high yields and ee.

Quinazoline deriviates for treating peptic ulcer

A quinazoline derivative represented by formula(I) or a pharmaceutically acceptable salt thereof is useful for the treatment of peptic ulcer, wherein: STR1 R1 and R2 are each hydrogen or a C1 -C4 alkyl group; R3 is hydrogen or a halogen; R4, R5, R6, R7, R8 and R9, which may be the same or different, are each hydrogen, a C1 -C4 alkyl group, a cyclopropyl group, or a C1 -C4 alkyl group substituted with a halogen; and R10 is a methoxy group.