1529760-72-2

Basic information

• Product Name: methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate
• Synonyms: methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate
• CAS NO: 1529760-72-2
• Molecular Formula: C₁₇H₁₇ClN₂O₃
• Molecular Weight: 332.78148
• Mol File: 1529760-72-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 434.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.278±0.06 g/cm3(Predicted)
• PKA: 10.74±0.70(Predicted)
• CAS DataBase Reference: methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate(1529760-72-2)
• EPA Substance Registry System: methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate(1529760-72-2)

Safety Data

• Hazardous Substances Data: 1529760-72-2(Hazardous Substances Data)

Upstream product

• 878207-92-2 methyl 6-chloro-3-methyl-pyridine-2-carboxylate 
• 3095-48-5 4-amino-3,5-dimethyl-benzoic acid methyl ester 
• 1529760-71-1 potassium 6-chloro-3-methyl-pyridine-2-carboxylate 
• 1201924-32-4 6-chloro-3-methyl-pyridine-2-carboxylic acid 
• 3277-04-1 3,5-dimethyl-4-nitro-benzoic acid methyl ester 
• 3095-38-3 3,5-dimethyl-4-nitrobenzoic acid 

Relevant articles and documents

Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists

Continued SAR optimization of a series of 3-methylpyridine-2-carbonyl amino-2,4-dimethyl-benzoic acid led to the selection of compound 4f for clinical studies. Compound 4f showed an IC50 of 123 nM for inhibition of PGE2-induced TNFα reduction i

DIMETHYL-BENZOIC ACID COMPOUNDS

The present invention provides a compound of the Formula II: wherein A is: * R 1 is CH3, CF 3, or F; * R 2 is H, CH3, or F; * R 3 is CH3, OCH 3, OH, F; R 4 is OH or CH 20H; and *