152982-56-4

Basic information

• Product Name: (3S,5S)-4-Benzoyl-5-tert-butyl-1,1-dimethyl-6-oxa-4-aza-spiro[2.4]heptan-7-one
• CAS NO: 152982-56-4
• Molecular Weight: 301.386
• Mol File: 152982-56-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,5S)-4-Benzoyl-5-tert-butyl-1,1-dimethyl-6-oxa-4-aza-spiro[2.4]heptan-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5S)-4-Benzoyl-5-tert-butyl-1,1-dimethyl-6-oxa-4-aza-spiro[2.4]heptan-7-one(152982-56-4)
• EPA Substance Registry System: (3S,5S)-4-Benzoyl-5-tert-butyl-1,1-dimethyl-6-oxa-4-aza-spiro[2.4]heptan-7-one(152982-56-4)

Safety Data

• Hazardous Substances Data: 152982-56-4(Hazardous Substances Data)

Upstream product

• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 113304-18-0 N-benzoyl-2(S)-tert-butyl-4-methylene-1,3-oxazolidin-5-one 

Downstream Products

• 130930-42-6 (1S)-1-amino-2,2-dimethylcyclopropane-1-carboxylic acid 

Relevant articles and documents

Synthesis of (R)- and (S)-2,3-Methanovaline from (2S)-N-Benzoyl-2-tert-butyl-4-methylene-1,3-oxazolidin-5-one

The reaction of (2S)-N-benzoyl-2-tert-butyl-4-methylene-1,3-oxazolidin-5-one (9) with isopropylidenetriphenylphosphorane at room temperature gives the corresponding cis and trans spirocyclopropane derivatives 10 in ca. 1:1 ratio.After separation of both diastereomers, by recrystallization and flasch chromatography, and further acid hydrolysis, enantiomerically pure (R)- and (S)-2,3-methanovaline 11 are obtained.