15307-68-3

Upstream product

• 15362-40-0 1-(2,6-dichlorophenyl)indolin-2-one 
• 100-52-7 benzaldehyde 
• 15308-01-7 2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide 
• 15307-93-4 N-phenyl-2,6-dichloroaniline 

Relevant academic research and scientific papers

In vitro cytotoxicity evaluation of diversely substituted N-aryl-2-oxindoles

In continuation with our previous work, structurally diverse 2-indolinones bearing 2,6-dichloroaryl fragment at N 1 and (hetero)aryl benzylidene at C3 were evaluated for their antitumor activity on a panel of cancer cell lines such as MCF-7 (breast), MiapaCa2 (pancreas), KB (oral), HuTu80 (stomach), L132 (lung), B16F10 (melanoma), and Molt4 (leukemia) from various human organs. Among the screened compound library, molecules 4e, 4k, and 4r have shown excellent cytotoxicity on a stomach cancer cell line. Moreover, a significant number of compounds have also shown promising cytotoxicity on pancreas and oral cancer cell lines.

Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line

A small library of 2-indolinone derivatives with the 2,6-dichlorophenyl ring at the N1 position and with varying substitutions including aryl groups at the 3-position were synthesized, and their structures were confirmed by spectral analysis. All molecules were screened for their in vitro cytotoxic activity on SW620 colon cancer cell lines. Among the designed series compounds 4c, 4f and 4j were found to be active at concentrations of 2-15 μg/ml. Some 3D-QSAR models were also built to understand the structure-activity relationship.