153085-14-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-methyl-3-(trifluoromethyl)-1H-pyrazole is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its ability to modify the biological activities of various compounds makes it a valuable component in the development of new drugs and pesticides.
Used in Medicinal Chemistry and Drug Discovery:
In the field of medicinal chemistry and drug discovery, 4-methyl-3-(trifluoromethyl)-1H-pyrazole is utilized for its potential to contribute to the design and synthesis of novel therapeutic agents. Its unique structure allows for the exploration of new chemical entities with improved pharmacological properties.
Used in Research and Development:
This chemical compound is also employed in research and development settings, where its interesting properties are studied and harnessed for the advancement of scientific knowledge and the creation of innovative applications across various industries.

Upstream product

• 7554-65-6 4-methyl-1H-pyrazole 
• 2314-97-8 iodotrifluoromethane 
• 4696-26-8 (E)-1-ethoxyprop-1-ene 
• 407-25-0 trifluoroacetic anhydride 
• 121781-56-4 (E)-4-ethoxy-1,1,1-trifluoro-3-methylbut-3-en-2-one 

Relevant academic research and scientific papers

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

LXR MODULATORS

The present invention provides compounds of Formula I and Formula II: or pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXRs), and compositions comprising any of such novel compounds and methods of use thereof. These compounds are useful as medicaments for treatment and/or prophylaxis for diseases or conditions related to activity of LXRs.

Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks

The pyrazole nucleus has recently become a recurrent scaffold in the research fields of CropScience and oncology. We report here the preparation of an array of 4- and 5-iodinated pyrazole derivatives, such as 4-iodo-3-trifluoromethylpyrazole or ethyl 5-io

Trifluoromethylation of various aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide

Trifluoromethylation of aromatic and hetero-aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide was investigated. Various trifluoromethylated benzene derivatives, six-membered nitrogen-containing aromatic compounds and five-membered hetero-aromatic compounds were obtained under mild conditions. General orientation of electrophilic substitution of aromatic compounds was observed similarly as reported in other radical trifluoromethylation previously.

REACTION REAGENT FOR TRIFLUOROMETHYLATION

Provided is a reaction reagent for trifluoromethylation with high general versatility and good efficiency. The reaction reagent for trifluoromethylation contains an iron compound, trifluoromethyl iodide, a sulfoxide and a peroxide, and may further contain an acid. The iron compound is, for example, iron(II) sulfate, ammonium iron(II) sulfate, iron(II) tetrafluoroborate, ferrocene, bis(η5-pentamethylcyclopentadienyl)iron or an iron powder; the sulfoxide is, for example, dimethyl sulfoxide; the peroxide is, for example, hydrogen peroxide or hydrogen peroxide-urea composite; and the acid is, for example, sulfuric acid, tetrafluoroboric acid or trifluoromethanesulfonic acid.

3-arylphenyl sulfide derivative and insecticide and miticide

3-Arylphenyl sulfide derivatives represented by general formula (I): (wherein R is a C2-C6alkyl group, a C2-C6alkenyl group, a C2-C6alkynyl group or the like, B0to B2a