7554-65-6 Usage
Description
Different sources of media describe the Description of 7554-65-6 differently. You can refer to the following data:
1. Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported.
2. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes metabolism of ethylene glycol and methanol to toxic metabolites. At 10 μM in monkeys, it can prevent the formation of toxic alcohol metabolites that generate metabolic acidosis. This compound is typically used as an antidote for ethylene glycol or methanol poisoning.
Chemical Properties
clear colourless to yellowish liquid after melting
Originator
Orphan Medical (US)
Uses
Different sources of media describe the Uses of 7554-65-6 differently. You can refer to the following data:
1. Useful as an antidote in methanol and ethylene glycol poisoning.
2. Antidote in methanol or ethylene glycol poisoning;Alcohol dehydrogenase inhibitor
3. antidote to ethylene glycol or methanol poisoning
4. Fomepizole (4-Methylpyrazole) can be used as: A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst. A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration. A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.
Definition
ChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Manufacturing Process
Preparation of 4-methylpyrazole
1.0 g (6.67 mmol) of sodium iodide is added to a suspension of 560 g (4.0
mol) of 70% strength sulfuric acid and 62.5 g (1.0 mol) of 80% strength
hydrazine hydrate and, at 125°C, 86.4 g (1.2 mol) of isobutyraldehyde are
pumped under the surface of the suspension over the course of 2 hours using
a metering pump. During and up to 100 min after the addition of
isobutyraldehyde, a total of 175 g of water was distilled out, with the
temperature of the mixture rising to 135°C. The solution is cooled and
adjusted to pH 8.6 with 820 g (5.125 mol) of 25% strength sodium
isobutyraldehyde hydroxide solution and is extracted with isobutanol. The
combined extracts are concentrated to 82 g in a rotary evaporator and then
distilled. The main fraction (boiling point 82°C/7 mbar; 49 g) consists of 82%
4-methylpyrazole. Yield: 49% of theory.
Brand name
Antizol (Jazz).
General Description
4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.
Biochem/physiol Actions
Alcohol dehydrogenase inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 7554-65-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,5 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 7554-65:
(6*7)+(5*5)+(4*5)+(3*4)+(2*6)+(1*5)=116
116 % 10 = 6
So 7554-65-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
7554-65-6Relevant articles and documents
4-methylpyrazole preparation method
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Paragraph 0018; 0019; 0020, (2017/07/22)
The invention discloses a 4-methylpyrazole preparation method. According to the preparation method, 3-amino-2-methylacrolein and formamide are utilized as main raw materials, methylbenzene is utilized as solvent, 4-methylpyrazole is prepared through normal-pressure reaction, and a 4-methylpyrazole finished product can be prepared by rectifying a crude product. The preparation method is simple, has moderate reaction conditions and avoids high-pressure reaction; the main raw materials are safe and environment-friendly; the product has high purity and is more favorable for industrial production.
ULTRAPURE 4-METHYLPYRAZOLE
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Page/Page column 8-9, (2008/06/13)
Disclosed is an ultrapure 4-methylpyrazole containing less than 0.1% pyrazole and containing less than 10 ppm each of hydrazine and nitrobenzaldehyde. The ultrapure 4-methylpyrazole is prepared by a novel process so that less than 0.01% of ethylvinyl ether is present.
Preparation of pyrazole and its derivatives
-
, (2008/06/13)
A process for preparing pyrazole and its derivatives of the formula I STR1 where R1, R2, R3 and R4 are each hydrogen, halogen, nitro, carboxyl, sulfonyl or C-organic radicals, from alpha,beta-unsaturated carbonyl compounds of the formula II STR2 and hydrazine or hydrazine derivatives of the formula III wherein, initially without additional diluent, an alpha,beta-unsaturated carbonyl compound of the formula II is reacted with hydrazine or a hydrazine derivative of the formula III, and the resulting reaction mixture is reacted in another step with a mixture of sulfuric acid and iodine or a compound which liberates iodine or hydrogen iodide.
