153108-45-3Relevant academic research and scientific papers
Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives
Ebiike, Hirosato,Maruyama, Kaori,Ozawa, Yumi,Yamazaki, Yukiyoshi,Achiwa, Kazuo
, p. 869 - 876 (2007/10/03)
Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot
ENZYME-CATALYZED SYNTHESIS OF BIOLOGICALLY ACTIVE (S)-NILVADIPINE
Ebiike, Hirosato,Ozawa, Yumi,Achiwa, Kazuo,Hirose, Yoshihiko,Kariya, Kinya,et al.
, p. 603 - 606 (2007/10/02)
Optically active 2-hydroxymethyl-1,4-dihydropyridine was obtained by lipase-catalyzed transestrification of isopropyl methyl 1,4-dihydro-2-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate.This chiral dihydropyridine was readily converted into biologically active (S)-nilvadipine.
