153219-23-9

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 87730-99-2 4-acetoxy-3-oxo-butyric acid methyl ester 
• 14205-46-0 isopropyl 3-aminocrotonate 
• 191742-12-8 isopropyl 2-acetoxymethyl-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3-methoxycarbonyl-5-piperidinecarboxylate 

Downstream Products

• 109545-30-4 (+)-Nilvadipine 
• 153108-45-3 (R)-isopropyl 2-formyl-1,4-dihydro-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-5-pyridinecarboxylate 

Relevant academic research and scientific papers

Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives

Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot

ENZYME-CATALYZED SYNTHESIS OF BIOLOGICALLY ACTIVE (S)-NILVADIPINE

Optically active 2-hydroxymethyl-1,4-dihydropyridine was obtained by lipase-catalyzed transestrification of isopropyl methyl 1,4-dihydro-2-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate.This chiral dihydropyridine was readily converted into biologically active (S)-nilvadipine.