15313-47-0Relevant academic research and scientific papers
Triphenylphosphine-catalyzed simple synthesis of dimethyl 1-aryl-4-ethoxy-5-oxo-4,5-dihydro-1H-pyrrole-2,3-dicarboxylates
Yavari, Issa,Aghazadeh, Mansoureh,Tafazzoli, Mohsen
, p. 1101 - 1107 (2002)
Ethyl 2-arylamino-2-oxo-acetates undergo a complex reaction with dimethyl acetylenedicarboxylate in the presence of triphenylphosphine to produce dimethyl 1-aryl-4-ethoxy-5-oxo-4,5-dihydro-1H-pyrrole-2,3-dicarboxylates in good yields. Dynamic NMR study of
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening
Lalonde, Judith M.,Elban, Mark A.,Courter, Joel R.,Sugawara, Akihiro,Soeta, Takahiro,Madani, Navid,Princiotto, Amy M.,Kwon, Young Do,Kwong, Peter D.,Sch?n, Arne,Freire, Ernesto,Sodroski, Joseph,Smith III, Amos B.
supporting information; experimental part, p. 91 - 101 (2011/02/28)
The low-molecular-weight compound JRC-II-191 inhibits infection of HIV-1 by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor and is therefore an important lead in the development of a potent viral entry inhibitor. Reported here is the use of two orthogonal screening methods, gold docking and ROCS shape-based similarity searching, to identify amine-building blocks that, when conjugated to the core scaffold, yield novel analogs that maintain similar affinity for gp120. Use of this computational approach to expand SAR produced analogs of equal inhibitory activity but with diverse capacity to enhance viral infection. The novel analogs provide additional lead scaffolds for the development of HIV-1 entry inhibitors that employ protein-ligand interactions in the vestibule of gp120 Phe 43 cavity.
SUBSTITUTED TRIAZOLECARBOXAMIDES
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Page 29, (2008/06/13)
Substituted triazolecarboxamides A b s t r a c t The invention relates to substituted triazolecarboxamides of the formula (I) in which R1, R2, R3 and R4 are as defined in the description, to their use as crop treatment agents, in particular as herbicides,
