153152-98-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 153077-97-5 (1R,2S,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide 
• 130372-24-6 (1R,1'S,2S,2'S)-2-<2'-<(Boc)amino>-1'-hydroxy-3'-phenylpropyl>cyclopentanecarboxylic acid lactone 
• 109-73-9 N-butylamine 
• 153152-96-6 (1R,4R,5S,1'S)-4-(1'-N-tert-butoxycarbonylamino-2'-phenyl)ethyl-3-oxobicyclo<3.3.0>octan-2-one 

Downstream Products

• 155320-54-0 (4S,5R,1'S,2'S)-4-benzyl-3-N-tert-butoxycarbonyl-5-(2'-n-butylaminocarbonyl)cyclopentyl-2,2-dimethyloxazolidine 
• 153152-96-6 (1R,4R,5S,1'S)-4-(1'-N-tert-butoxycarbonylamino-2'-phenyl)ethyl-3-oxobicyclo<3.3.0>octan-2-one 
• 155320-50-6 (4S,5R,1'S,2'R)-4-benzyl-3-N-tert-butoxycarbonyl-5-(2'-n-butylaminocarbonyl)cyclopentyl-2,2-dimethyloxazolidine 

Relevant academic research and scientific papers

A new synthetic route for the γ-lactone precursors of hydroxyethylene dipeptide isosteres

δ-Phthalimido-γ-ketoesters were obtained by the Pd catalyzed coupling reaction between acid chlorides and organozinc reagents derived from β-iodoesters, and were converted into the γ-lactones precursors of Phe-ψ[H.E.]-Ala and Phe-ψ[H.E.]-Pro (15a,b-18a,b).

Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-Ψ[H.E.]-Pro), four ster