1531585-35-9Relevant academic research and scientific papers
Synthesis of the spiroacetal core of the cephalosporolide family of natural products
Finch, Orla C.,Furkert, Daniel P.,Brimble, Margaret A.
, p. 590 - 596 (2014/02/14)
The synthesis of four possible stereoisomers of the spiroacetal core of the natural products cephalosporolides H and I and penisporolides A and B is described. The key steps involve the use of Sharpless asymmetric dihydroxylation to install the desired stereochemistry of the γ-lactone ring and an oxidative radical cyclisation to form the spiroacetal ring system.
