1531586-73-8

Basic information

• Product Name: (R)-4-methyl-2-(2-oxo-2-((R)-2-oxo-4-phenyloxazolidin-3-yl)ethyl)pentanenitrile
• CAS NO: 1531586-73-8
• Molecular Weight: 300.357
• Mol File: 1531586-73-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-methyl-2-(2-oxo-2-((R)-2-oxo-4-phenyloxazolidin-3-yl)ethyl)pentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-methyl-2-(2-oxo-2-((R)-2-oxo-4-phenyloxazolidin-3-yl)ethyl)pentanenitrile(1531586-73-8)
• EPA Substance Registry System: (R)-4-methyl-2-(2-oxo-2-((R)-2-oxo-4-phenyloxazolidin-3-yl)ethyl)pentanenitrile(1531586-73-8)

Safety Data

• Hazardous Substances Data: 1531586-73-8(Hazardous Substances Data)

Upstream product

• 41653-96-7 (E)-5-methyl-2-hexenoic acid 
• 34993-63-0 ethyl (E)-5-methylhex-2-enoate 
• 590-86-3 isovaleraldehyde 
• 5804-85-3 diethylaluminium cyanide 
• 261896-46-2 (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one 

Relevant articles and documents

Diasteroselective conjugate addition of diethylaluminum cyanide to a conjugated N -enoyl system: An alternative synthesis of (S)-pregabalin

We have explored in this work the conjugate addition of diethylaluminum cyanide (Nagata's reagent) to an N-enoyl system bearing the (R)-4-phenyl-2- oxazolidinone chiral auxiliary. Since this method provided a practical synthesis of γ-amino acids, we report the conjugate addition of diethylaluminum cyanide as the key step in the synthesis of (S)-pregabalin 1 in a five-step sequence of reactions from commercially available starting materials.