1531590-65-4Relevant articles and documents
Collective Synthesis of cladiellins based on the gold-catalyzed cascade reaction of 1,7-diynes
Yue, Guozong,Zhang, Yun,Fang, Lichao,Li, Chuang-Chuang,Luo, Tuoping,Yang, Zhen
, p. 1837 - 1840 (2014/03/21)
The cladiellin family of natural products, which includes molecules with various biological activities, continues to invite new synthetic studies. A gold-catalyzed tandem reaction of 1,7-diynes to construct the 6-5-bicyclic ring systems that are present in a number of natural products was developed. This reaction was applied as the key step to realize the formal and total syntheses of nine members of the cladiellin family in an enantio- and diastereoselective manner. This modular and efficient approach could also be used for the construction of other cladiellins, as well as their analogues, for follow-up studies. Clad(iellins) in gold: A gold-catalyzed tandem reaction of 1,7-diynes was previously developed to construct the 6-5-bicyclic ring systems that are present in a number of natural products. This reaction was applied to realize the total synthesis of nine members of the cladiellin family. This modular and efficient approach, which is enantio- and stereoselective, could also be used for the construction of other cladiellins and their analogues. Copyright