1531593-98-2

Upstream product

• 1531593-73-3 ethyl 4-{4-[(2-ethoxy-2-oxoethyl)amino]-2-fluorophenyl}piperazine-1-carboxylate 
• 872-85-5 pyridine-4-carbaldehyde 
• 1531593-74-4 ethyl 4-{2-fluoro-4-[(2-hydrazinyl-2-oxoethyl)amino]phenyl}piperazine-1-carboxylate 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 351041-31-1 ethyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate 
• 369-34-6 3,4-difluoronitrobenzene 
• 952919-05-0 ethyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

Microwave-Assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities

Ethyl 4-Amino-2-fluorophenylpiperazin-1-carboxylates containing a 1,3-oxazol(idin)e, 5-thioxo-1,2,4-triazole, 1,3,4-thiadiazole, 5-thioxo-1,3,4-oxadiazole, or 1,3-thiazole nucleus were obtained starting from ethyl piperazine-1-carboxylate (1) by several steps. The treatment of amine, 3 or hydrazide, 9 with several aromatic aldehydes generated the corresponding arylmethyleneamino (3a-f) or arylidenehydrazino (12a-c) compounds. The Mannich reaction between the 1,2,4-triazole or 1,3,4-oxadiazole compounds and 7-Aca produced cephalosporanic acid derivatives. Penicillanic acid derivatives were obtained when 6-Apa was used in the Mannich reactions. The synthesized compounds were screened for their antimicrobial, antilipase, and antiurease activities. Some of them were found to possess good-moderate antimicrobial activity against the test microorganisms. Two compounds exhibited antiurease activity, and four of them displayed antilipase activity.