952919-05-0

Upstream product

• 369-34-6 3,4-difluoronitrobenzene 
• 351041-31-1 ethyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate 
• 120-43-4 4-ethoxycarbonylpiperazine 

Downstream Products

• 1531593-71-1 ethyl 4-(4-{[3-benzyl-4-oxo-1,3-oxazolidin-2-ylidene]amino}-2-fluorophenyl)piperazine-1-carboxylate 
• 1531593-74-4 ethyl 4-{2-fluoro-4-[(2-hydrazinyl-2-oxoethyl)amino]phenyl}piperazine-1-carboxylate 
• 1531593-75-5 ethyl 4-(2-fluoro-4-{[2-(2-{[(4-fluorophenyl)amino]carbonothioyl}hydrazino)-2-oxoethyl]amino}phenyl)piperazine-1-carboxylate 
• 1531593-76-6 ethyl 4-[4-({2-[2-(anilinocarbonothioyl)hydrazino]-2-oxoethyl}amino)-2-fluorophenyl] piperazine-1-carboxylate 
• 1531593-77-7 ethyl 4-(4-{[(5-anilino-1,3,4-thiadiazol-2-yl)methyl]amino}-2-fluorophenyl)piperazine-1-carboxylate 
• 1531593-78-8 ethyl 4-[2-fluoro-4-({[4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl}amino)phenyl]piperazine-1-carboxylate 
• 1531593-79-9 ethyl 4-(2-fluoro-4-{[(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]amino}phenyl)piperazine-1-carboxylate 
• 1531593-81-3 ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)triethyl ammonium 
• 1531593-83-5 [({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium 
• 1531593-86-8 ethyl 4-[4-(3-{2-[5-(4-chlorophenyl)-3-phenyl-1,3-thiazol-2(3H)-ylidene]hydrazino}-3-oxoethyl)-2-fluorophenylamino]piperazine-1-carboxylate 
• 1531593-87-9 ethyl 4-[2-fluoro-4-({2-[2-(3-hydroxy-4-methoxybenzylidene)hydrazino]-2-oxoethyl}amino)phenyl]piperazine-1-carboxylate 
• 1531593-98-2 ethyl 4-[2-fluoro-4-({2-oxo-2-[2-(pyridin-4-ylmethylene)hydrazino]ethyl}amino)phenyl]piperazine-1-carboxylate 
• 1531593-99-3 ethyl 4-[2-fluoro-4-({2-[2-(2-hydroxybenzylidene)hydrazino]-2-oxoethyl}amino)phenyl]piperazine-1-carboxylate 
• 1531593-88-0 ethyl 4-(2-fluoro-4-{[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]amino}phenyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

Microwave-Assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities

Ethyl 4-Amino-2-fluorophenylpiperazin-1-carboxylates containing a 1,3-oxazol(idin)e, 5-thioxo-1,2,4-triazole, 1,3,4-thiadiazole, 5-thioxo-1,3,4-oxadiazole, or 1,3-thiazole nucleus were obtained starting from ethyl piperazine-1-carboxylate (1) by several steps. The treatment of amine, 3 or hydrazide, 9 with several aromatic aldehydes generated the corresponding arylmethyleneamino (3a-f) or arylidenehydrazino (12a-c) compounds. The Mannich reaction between the 1,2,4-triazole or 1,3,4-oxadiazole compounds and 7-Aca produced cephalosporanic acid derivatives. Penicillanic acid derivatives were obtained when 6-Apa was used in the Mannich reactions. The synthesized compounds were screened for their antimicrobial, antilipase, and antiurease activities. Some of them were found to possess good-moderate antimicrobial activity against the test microorganisms. Two compounds exhibited antiurease activity, and four of them displayed antilipase activity.