1531605-27-2

Upstream product

• 127119-08-8 3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 2328-12-3 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride 
• 3586-58-1 2-methylenebutyric acid 
• 1531605-26-1 tert-butyl-1-(2-(((tert-butyldiphenylsilyl)oxy)methyl)allyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 913253-34-6 {[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane 
• 177606-51-8 2-<(tert-butyldiphenylsilyloxy)methyl>prop-2-en-1-ol 

Downstream Products

• 1531605-44-3 2-((2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-ethyl-6,7-dihydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one 

Relevant academic research and scientific papers

The synthesis and structure revision of NSC-134754

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF.